Expression of resistance to methicillin

Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus

1985 • 363 citations

Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci

1991 • 303 citations

Evolution of an inducible penicillin‐target protein in methicillin‐resistant Staphylococcus aureus by gene fusion

1987 • 301 citations

New mechanism for methicillin resistance in Staphylococcus aureus: clinical isolates that lack the PBP 2a gene and contain normal penicillin-binding proteins with modified penicillin-binding capacity

1989 • 296 citations

FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: Molecular cloning and characterization

1989 • 208 citations

blaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus

1993 • 184 citations

Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin‐resistant Staphylococcus aureus (MRSA)

1992 • 182 citations

femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains

1991 • 181 citations

Molecular aspects of methicillin resistance in Staphylococcus aureus

1994 • 174 citations

Origin and evolution of DNA associated with resistance to methicillin in staphylococci

1994 • 172 citations

Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus

1989 • 168 citations

Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus

1992 • 159 citations

Correlation between regulation of mecA transcription and expression of methicillin resistance in staphylococci

1992 • 156 citations

Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus

1993 • 152 citations

Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains

1993 • 150 citations

Survey of methicillin-resistant clinical strains of coagulase-negative staphylococci for mecA gene distribution

1992 • 148 citations

Mechanisms of heteroresistance in methicillin-resistant Staphylococcus aureus

1994 • 134 citations

The femC locus of Staphylococcus aureus required for methicillin resistance includes the glutamine synthetase operon

1994 • 105 citations

Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus

1993 • 102 citations

Abnormal Peptidoglycan Produced in a Methicillin-Resistant Strain of Staphylococcus aureus Grown in the Presence of Methicillin: Functional Role for Penicillin-Binding Protein 2A in Cell Wall Synthesis

1993 • 96 citations

Peptidoglycan composition in heterogeneous Tn551 mutants of a methicillin-resistant Staphylococcus aureus strain.

1992 • 94 citations

Methicillin-resistant strains ofStaphylococcus aureus; presence of identical additional penicillin-binding protein in all strains examined

1986 • 91 citations

Evidence of a novel staphylococcal mec-encoded element (mecR) controlling expression of penicillin-binding protein 2'

1990 • 90 citations

Analysis of Borderline‐Resistant Strains of Methicillin‐Resistant Staphylococcus aureus Using Polymerase Chain Reaction

1992 • 79 citations

Cloning and expression of methicillin resistance from Staphylococcus epidermidis in Staphylococcus carnosus

1988 • 70 citations

Resistance heterogeneity in methicillin-resistantStaphylococcus aureus

1984 • 65 citations

The Expression in Staphylococcus aureus of Cloned DNA Encoding Methicillin Resistance

1988 • 61 citations

Borderline susceptibility to antistaphylococcal penicillins is not conferred exclusively by the hyperproduction of beta-lactamase

1991 • 61 citations

Autolysis of methicillin-resistant and -susceptible Staphylococcus aureus

1992 • 60 citations

Staphylococcus aureus has clustered tRNA genes

1993 • 59 citations

Consequences of the interaction of ?-lactam antibiotics with penicillin binding proteins from sensitive and resistant Staphylococcus aureus strains

1992 • 58 citations

Genetic control of population structure in heterogeneous strains of methicillin resistantStaphylococcus aureus

1993 • 54 citations

Natural methicillin resistance in comparison with that selected by in-vitro drug exposure in Staphylococcus aureus

1989 • 43 citations

Wall peptidoglycan in Aerococcus viridans strains 201 Evans and ATCC 11563 and in Gaffkya homari strain ATCC 10400

1971 • 42 citations

The peptidoglycan composition of a Staphylococcus aureus mutant selected for reduced methicillin resistance.

1993 • 41 citations

Bacterial growth and lysis: Metabolism and structure of the bacterial sacculus

1993 • 37 citations

Methicillin resistance in Staphylococcus epidermidis

1989 • 29 citations

Co-elimination of mec and spa genes in Staphylococcus aureus and the effect of agr and protein A production on bacterial adherence to cell monolayers

1993 • 27 citations

Site-directed mutagenesis of the mecA gene from a methicillin-resistant strain of Staphylococcus aureus

1994 • 25 citations

Benefit and risk in the β-lactam antibiotic-resistance strategies of Streptococcus pneumoniae and Staphylococcus aureus

1994 • 21 citations

Differential Depression of Staphylococcal Plasmid and Chromosomal Penicillinase Genes by a Class of Unlinked Chromosomal Mutations (R2 ⁻ )

1970 • 9 citations