The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)

2002 • 1,552 citations

Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

2002 • 414 citations

An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci

2001 • 370 citations

Evaluation of Current Methods for Detection of Staphylococci with Reduced Susceptibility to Glycopeptides

2001 • 323 citations

The evolution of methicillin resistance in Staphylococcus aureus : Similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones

2001 • 314 citations

BOCILLIN FL, a Sensitive and Commercially Available Reagent for Detection of Penicillin-Binding Proteins

1999 • 281 citations

Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases

2001 • 223 citations

Biochemistry and Comparative Genomics of SxxK Superfamily Acyltransferases Offer a Clue to the Mycobacterial Paradox: Presence of Penicillin-Susceptible Target Proteins versus Lack of Efficiency of Penicillin as Therapeutic Agent

2002 • 197 citations

Treatment of methicillin-resistant Staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy

2000 • 162 citations

TAK-599, a novel N-Phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties

2003 • 132 citations

Jumping the Barrier to β-Lactam Resistance in Staphylococcus aureus

2003 • 94 citations

BAL9141, a Novel Extended-Spectrum Cephalosporin Active against Methicillin-Resistant Staphylococcus aureus in Treatment of Experimental Endocarditis

2002 • 93 citations

A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis

2001 • 91 citations

Efficacy of Linezolid in Treatment of Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus

2001 • 81 citations

Resistance to β-Lactam Antibiotics and Its Mediation by the Sensor Domain of the Transmembrane BlaR Signaling Pathway in Staphylococcus aureus

2003 • 79 citations

How β-Lactamases Have Driven Pharmaceutical Drug Discovery

1998 • 78 citations

Possible physiological functions of penicillin-binding proteins in Staphylococcus aureus

1986 • 74 citations

Penicillin-Binding Protein 2a from Methicillin-Resistant Staphylococcus aureus: Kinetic Characterization of Its Interactions with β-Lactams Using Electrospray Mass Spectrometry

1999 • 72 citations

PBP 2a Mutations Producing Very-High-Level Resistance to Beta-Lactams

2004 • 70 citations

Kinetics of β-Lactam Interactions with Penicillin-susceptible and -resistant Penicillin-binding Protein 2x Proteins from Streptococcus pneumoniae

2001 • 69 citations

The in vitro activity of daptomycin against Staphylococcus aureus and Enterococcus species

2003 • 62 citations

Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with β-lactams and acyclic substrates: kinetics in homogeneous solution

1998 • 55 citations

First Case of VRSA Identified in Michigan

2002 • 54 citations

Penicillin binding protein 2x as a major contributor to intrinsic β‐lactam resistance of Streptococcus pneumoniae

1993 • 46 citations

Massive Reduction in Methicillin Resistance by Transposon Inactivation of the Normal PBP2 in a Methicillin-Resistant Strain ofStaphylococcus aureus

1997 • 43 citations

Altered production of penicillin-binding protein 2a can affect phenotypic expression of methicillin resistance in Staphylococcus aureus

1994 • 43 citations

RWJ-54428 (MC-02,479), a New Cephalosporin with High Affinity for Penicillin-Binding Proteins, Including PBP 2a, and Stability to Staphylococcal Beta-Lactamases

2003 • 29 citations

Site-directed mutagenesis of the mecA gene from a methicillin-resistant strain of Staphylococcus aureus

1994 • 25 citations

Purification, properties, and kinetics of enzymatic acylation with beta-lactams of soluble penicillin-binding protein 2a. A major factor in methicillin-resistant Staphylococcus aureus.

1994 • 17 citations

Identification of the active site serine of penicillin-binding protein 2a from methicillin-resistantStaphylococcus aureus by electrospray mass spectrometry

1998 • 12 citations