Mutations of PIK3CAin gastric adenocarcinoma

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Missing value estimation methods for DNA microarrays

2001 • 3,768 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

2002 • 1,465 citations

RAF/RAS oncogenes and mismatch-repair status

2002 • 1,205 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

2001 • 1,153 citations

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

2004 • 1,054 citations

AKT plays a central role in tumorigenesis

2001 • 932 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

2001 • 505 citations

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

2001 • 449 citations

PIK3CA as an oncogene in cervical cancer

2000 • 432 citations

Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

2002 • 408 citations

PTEN: from pathology to biology

2003 • 345 citations

Variation in Gene Expression Patterns in Human Gastric Cancers

2003 • 316 citations

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

2002 • 232 citations

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma

2003 • 185 citations

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

2002 • 183 citations

PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers

2002 • 182 citations

Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

2002 • 154 citations

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

2000 • 125 citations

Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis

2003 • 99 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations