Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis

AJCC Cancer Staging Manual

2010 • 5,917 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1999 • 631 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 • 510 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

1998 • 453 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

2002 • 389 citations

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

2000 • 385 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 368 citations

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

2002 • 341 citations

Akt Participation in the Wnt Signaling Pathway through Dishevelled

2001 • 326 citations

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis

1998 • 319 citations

Amplification and overexpression of theAKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1998 • 318 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

2002 • 232 citations

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

2000 • 231 citations

Promoter Methylation and Silencing of PTEN in Gastric Carcinoma

2002 • 227 citations

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

2000 • 216 citations

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain

1999 • 198 citations

Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and βγ Subunits of G Proteins

1995 • 189 citations

MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas

2001 • 189 citations

Tumour suppressor gene expression correlates with gastric cancer prognosis

2003 • 185 citations

Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways

2000 • 88 citations

Insulin-like Growth Factor (IGF)-I Regulates IGF-binding Protein-5 Gene Expression through the Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and p70 S6 Kinase Signaling Pathway

1999 • 84 citations

Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer

2002 • 46 citations

Bcl-2 expression and allelic loss of thep53 gene in gastric carcinomas

1996 • 26 citations

Intramucosal Carcinomas of the Stomach: Phenotypic Expression and Loss of Heterozygosity at Microsatellites Linked to the APC Gene

1998 • 21 citations