Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

1974 • 1,479 citations

Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells

1968 • 874 citations

ADP-RIBOSYLATION

1985 • 710 citations

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

1975 • 616 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes

1983 • 423 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Size, Composition, and Structure of the Deoxyribonucleic Acid of Herpes Simplex Virus Subtypes 1 and 2

1971 • 380 citations

DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation

1982 • 351 citations

Poly(ADP-ribose) levels in carcinogen-treated cells

1979 • 346 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants

1978 • 339 citations

On the formation of a novel adenylic compound by enzymatic extracts of liver nuclei

1966 • 337 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

Proteins Specified by Herpes Simplex Virus XI. Identification and Relative Molar Rates of Synthesis of Structural and Nonstructural Herpes Virus Polypeptides in the Infected Cell

1973 • 317 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4

1985 • 273 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Regulation of herpesvirus macromolecular synthesis V. Properties of α polypeptides made in HSV-1 and HSV-2 infected cells

1977 • 253 citations

Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA

1980 • 251 citations

Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4

1988 • 225 citations

Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies

1984 • 184 citations

Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus.

1984 • 178 citations

Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27

1988 • 167 citations

Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA

1986 • 165 citations

Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B

1977 • 163 citations

Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.

1983 • 159 citations

Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site

1987 • 158 citations

Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes.

1986 • 154 citations

Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein

1988 • 149 citations

Abnormal properties of an immediate early polypeptide in cells infected with the herpes simplex virus type 1 mutant tsK

1979 • 146 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection

1990 • 124 citations

Molecular genetics of herpes simplex virus: Demonstration of regions of obligatory and nonobligatory identity within diploid regions of the genome by sequence replacement and insertion

1978 • 115 citations

Modification of SV40 T antigen by poly ADP-ribosylation

1981 • 110 citations

Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate early gene products

1986 • 105 citations

Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.

1987 • 97 citations

Herpes simplex Virus a Protein ICP27 Can Inhibit or Augment Viral Gene Transactivation

1989 • 94 citations

Isolation of herpes simplex virus regulatory protein ICP4 as a homodimeric complex

1985 • 93 citations

Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors

1987 • 92 citations

Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression

1988 • 88 citations

The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation

1988 • 87 citations

Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription.

1986 • 82 citations

Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly

1991 • 74 citations

Studies on anti-poly(adenosine diphosphate ribose) antibody

1974 • 71 citations

Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site

1988 • 62 citations

Rapid assay of poly(ADP-ribose) glycohydrolase

1987 • 58 citations

Labeling methods for the study of poly- and mono(ADP-ribose) metabolism in cultured cells

1988 • 57 citations

Evaluation of immobilized boronates for studies of adenine and pyridine nucleotide metabolism

1983 • 55 citations

ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4

1989 • 49 citations

Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4

1989 • 49 citations

An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase

1990 • 46 citations

Poly(ADP-ribosyl)ation of a herpes simplex virus immediate early polypeptide

1983 • 45 citations

Binding of the herpes simplex virus major regulatory protein to viral DNA.

1989 • 43 citations

Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1

1988 • 33 citations

ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated

1991 • 32 citations

The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA.

1991 • 31 citations

Regulation of herpesvirus macromolecular synthesis: temporal order of transcription of alpha genes is not dependent on the stringency of inhibition of protein synthesis

1981 • 31 citations

DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element

1989 • 31 citations

Immunoaffinity fractionation of the poly(ADP-ribosyl)ated domains of chromatin.

1983 • 30 citations

Poly(ADP-ribose) polymerase inhibitors suppress UV-induced human immunodeficiency virus type 1 gene expression at the posttranscriptional level.

1991 • 27 citations

Relationship between histone H1 poly(adenosine diphosphate-ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate-ribose) antibody

1983 • 25 citations

Characterization of a herpes simplex virus regulatory protein: Aggregation and phosphorylation of a temperature-sensitive variant of ICP 4

1986 • 23 citations

In vivo characterization of the poly(ADP-ribosylation) of SV40 chromatin and large T antigen by immunofractionation

1987 • 19 citations

Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins

1983 • 16 citations

[53] Poly(ADP-ribose) glycohydrolase and phosphodiesterases in the analysis of poly(ADP-ribosyl)ated proteins

1984 • 3 citations

Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate

1989 • 2 citations

Viral Hepatitis in Mice and ADP-Ribose Metabolism

1989 • 1 citations