ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

1974 • 1,479 citations

Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells

1968 • 874 citations

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

1975 • 616 citations

GTP-binding domain: three consensus sequence elements with distinct spacing.

1987 • 602 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Size, Composition, and Structure of the Deoxyribonucleic Acid of Herpes Simplex Virus Subtypes 1 and 2

1971 • 380 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants

1978 • 339 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

Proteins Specified by Herpes Simplex Virus XI. Identification and Relative Molar Rates of Synthesis of Structural and Nonstructural Herpes Virus Polypeptides in the Infected Cell

1973 • 317 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4

1985 • 273 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Regulation of herpesvirus macromolecular synthesis V. Properties of α polypeptides made in HSV-1 and HSV-2 infected cells

1977 • 253 citations

Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA

1980 • 251 citations

Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4

1988 • 225 citations

Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies

1984 • 184 citations

Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA

1986 • 165 citations

Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site

1987 • 158 citations

Recombinants between herpes simplex virus types 1 and 2: analyses of genome structures and expression of immediate early polypeptides

1978 • 157 citations

Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein

1988 • 149 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

RNA unwinding activity of SV40 large T antigen

1989 • 135 citations

The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+

1990 • 129 citations

DNA-binding site of major regulatory protein alpha 4 specifically associated with promoter-regulatory domains of alpha genes of herpes simplex virus type 1.

1986 • 109 citations

Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate early gene products

1986 • 105 citations

Isolation of herpes simplex virus regulatory protein ICP4 as a homodimeric complex

1985 • 93 citations

Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors

1987 • 92 citations

Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression

1988 • 88 citations

The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation

1988 • 87 citations

Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription.

1986 • 82 citations

Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly

1991 • 74 citations

Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site

1988 • 62 citations

ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4

1989 • 49 citations

Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4

1989 • 49 citations

Poly(ADP-ribosyl)ation of a herpes simplex virus immediate early polypeptide

1983 • 45 citations

Binding of the herpes simplex virus major regulatory protein to viral DNA.

1989 • 43 citations

A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties

1991 • 37 citations

Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1

1988 • 33 citations

DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element

1989 • 31 citations

The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA.

1991 • 31 citations

Interaction of cell and virus proteins with DNA sequences encompassing the promoter/regulatory and leader regions of the herpes simplex virus thymidine kinase gene.

1990 • 24 citations

Characterization of a herpes simplex virus regulatory protein: Aggregation and phosphorylation of a temperature-sensitive variant of ICP 4

1986 • 23 citations

A mutant of herpes simplex virus type 1 immediate early polypeptide Vmw175 binds to the cap site of its own promoter in vitro but fails to autoregulate in vivo

1990 • 23 citations

Mutants defective in herpes simplex virus type 2 ICP4: isolation and preliminary characterization

1987 • 21 citations

Characterization of DNA-protein complex formation in nuclear extracts with a sequence from the herpes simplex virus thymidine kinase gene.

1990 • 17 citations

Intertypic recombinants of herpes simplex virus types 1 and 2 infected-cell polypeptide 4

1987 • 4 citations