Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not <scp>l</scp>-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

1977 • 791 citations

Complete nucleotide sequences of the gene for human factor IX (antihemophilic factor B)

1985 • 683 citations

Isolation and characterization of a cDNA coding for human factor IX.

1982 • 415 citations

The gene structure of human anti-haemophilic factor IX.

1984 • 361 citations

Activation of human factor IX (Christmas factor).

1978 • 258 citations

The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.

1988 • 240 citations

A Simplified Procedure for Purification of Human Prothrombin, Factor IX and Factor X

1981 • 222 citations

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

1982 • 220 citations

Identification of a Nondeletion Defect in α-Thalassemia

1977 • 194 citations

Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor)

1977 • 189 citations

Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position −4

1986 • 176 citations

A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells

1988 • 174 citations

Kinetics of factor IX activation via the extrinsic pathway. Dependence of Km on tissue factor.

1980 • 157 citations

Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor.

1986 • 129 citations

Genetic variants of hemophilia B: detection by means of a specific PTC inhibitor

1968 • 103 citations

An investigation of three patients with Christmas disease due to an abnormal type of factor ix

1968 • 101 citations

Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.

1983 • 93 citations

An alternative extrinsic pathway of human blood coagulation

1982 • 93 citations

Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.

1985 • 85 citations

Hemophilia B: characterization of genetic variants and detection of carriers

1977 • 84 citations

The putative factor IX gene promoter in hemophilia B Leyden

1988 • 84 citations

Cooperative Ca2+ binding to human factor IX. Effects of Ca2+ on the kinetic parameters of the activation of factor IX by factor XIa.

1982 • 82 citations

Activation of human factor VII by activated factors IX and X

1982 • 76 citations

Tissue factor-dependent activation of tritium-labeled factor IX and factor X in human plasma

1984 • 70 citations

A monoclonal antibody to factor IX that inhibits the factor VIII:Ca potentiation of factor X activation.

1985 • 65 citations

Redetermination of the rate-limiting step in the activation of factor IX by factor XIa and by factor VIIa/tissue factor. Explanation for different electrophoretic radioactivity profiles obtained on activation of 3H- and 125I-labeled factor IX

1983 • 61 citations

Sensitive proteolytic enzyme assay using differential solubilities of radioactive substrates and products in biphasic systems

1970 • 61 citations

Factor IXAlabama: a point mutation in a clotting protein results in hemophilia B

1987 • 60 citations

The Genetic Heterogeneity of Hemophilia B

1970 • 48 citations

Structure and Function of Factor IX: Defects in Haemophilia B

1985 • 42 citations

A moderate form of hemophilia B is caused by a novel mutation in the protease domain of factor IXVancouver

1989 • 34 citations

Molecular defect in factor IXHilo, a hemophilia Bm variant: Arg----Gln at the carboxyterminal cleavage site of the activation peptide

1989 • 32 citations

Intrinsic versus extrinsic coagulation Kinetic considerations

1986 • 30 citations

Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site.

1985 • 30 citations

Genetic defect responsible for the dysfunctional protein: factor IXLong Beach

1988 • 29 citations

Purification and Properties of an Abnormal Blood Coagulation Factor IX (Factor IXBm)/Kinetics of Its Inhibition of Factor X Activation by Factor VII and Bovine Tissue Factor

1981 • 29 citations

Molecular defect in factor IXBm Lake Elsinore. Substitution of Ala390 by Val in the catalytic domain.

1988 • 28 citations

Factor IX Deventer-Evidence for the Heterogeneity of Hemophilia BM

1982 • 18 citations

Factor VII Activity and Antigen in Haemophilia B Variants

1980 • 6 citations