Post‐transcriptional Compartmentalization of Acetylcholine Receptor Biosynthesis in the Subneural Domain of Muscle and Electrocyte Junctions

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Intermediate filaments as mechanical integrators of cellular space

1980 • 1,973 citations

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

1988 • 1,501 citations

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

1992 • 1,381 citations

Membrane organization of the dystrophin-glycoprotein complex

1991 • 1,321 citations

The neurosciences. Fourth study program

1980 • 1,165 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Characterization of Dystrophin in Muscle-Biopsy Specimens from Patients with Duchenne's or Becker's Muscular Dystrophy

1988 • 910 citations

Plasticity of the Differentiated State

1985 • 839 citations

Cytoplasmic activation of human nuclear genes in stable heterocaryons

1983 • 839 citations

Control of acetylcholine receptors in skeletal muscle

1979 • 770 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

The Agrin Hypothesis

1990 • 637 citations

Duchenne muscular dystrophy: Deficiency of dystrophin at the muscle cell surface

1988 • 617 citations

The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium.

1989 • 498 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

An autosomal transcript in skeletal muscle with homology to dystrophin

1989 • 478 citations

Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers.

1976 • 383 citations

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

1977 • 375 citations

Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle

1991 • 368 citations

Acetylcholine receptor turnover in membranes of developing muscle fibers.

1975 • 364 citations

Developmental Regulation of Nicotinic Acetylcholine Receptors

1987 • 354 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

Microtubule dynamics in interphase cells.

1986 • 331 citations

Localization of muscle gene products in nuclear domains

1989 • 313 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Lamin B constitutes an intermediate filament attachment site at the nuclear envelope.

1987 • 306 citations

Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein

1989 • 274 citations

Dynamic and stable populations of microtubules in cells.

1987 • 273 citations

Immunolocalization and developmental expression of dystrophin related protein in skeletal muscle

1991 • 261 citations

Agrin induces phosphorylation of the nicotinic acetylcholine receptor

1991 • 253 citations

Myogenic lineage determination and differentiation: Evidence for a regulatory gene pathway

1988 • 253 citations

Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.

1984 • 248 citations

Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.

1987 • 247 citations

The postsynaptic 43k protein clusters muscle nicotinic acetylcholine receptors in xenopus oocytes

1990 • 237 citations

The vertebrate neuromuscular junction

1986 • 235 citations

Microtubules, membrane traffic, and cell organization

1990 • 229 citations

Nicotinic acetylcholine receptors in vertebrate muscle: Properties, distribution and neural control

1985 • 229 citations

Microtubule Dynamics: Mechanism, Regulation, and Function

1991 • 228 citations

The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle.

1991 • 228 citations

Two distinct attachment sites for vimentin along the plasma membrane and the nuclear envelope in avian erythrocytes: a basis for a vectorial assembly of intermediate filaments.

1987 • 227 citations

Detection of the nicotinic acetylcholine receptor alpha-subunit mRNA by in situ hybridization at neuromuscular junctions of 15-day-old chick striated muscles.

1988 • 217 citations

The neural network underlying locomotion in lamprey-synaptic and cellular mechanisms

1991 • 203 citations

ACh Receptor-Rich Membrane Domains Organized in Fibroblasts by Recombinant 43-Kilodalton Protein

1991 • 202 citations

Imprinting of acetylcholine receptor messenger RNA accumulation in mammalian neuromuscular synapses

1990 • 200 citations

Development of the neuromuscular junction in the chick embryo: The number, distribution, and stability of acetylcholine receptors

1977 • 199 citations

Differential regulation of muscle acetylcholine receptor γ‐and ϵ‐subunit mRNAs

1987 • 197 citations

Crosslinking of proteins in acetylcholine receptor-rich membranes: Association between the β-subunit and the 43 kd subsynaptic protein

1983 • 197 citations

The submembrane machinery for nicotinic acetylcholine receptor clustering.

1991 • 176 citations

Axonal tubulin and axonal microtubules: biochemical evidence for cold stability.

1984 • 167 citations

Loss of alpha‐bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm muscle in vivo and in organ culture.

1975 • 165 citations

Small GTP-binding proteins and their role in transport

1991 • 164 citations

Ultrastructural localization of the Mr 43,000 protein and the acetylcholine receptor in Torpedo postsynaptic membranes using monoclonal antibodies.

1984 • 164 citations

Newly synthesized acetylcholine receptors are located in the Golgi apparatus.

1978 • 160 citations

Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin.

1983 • 153 citations

Activity regulates the levels of acetylcholine receptor alpha-subunit mRNA in cultured chicken myotubes.

1985 • 153 citations

Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.

1978 • 150 citations

Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin.

1989 • 148 citations

Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick.

1989 • 146 citations

Cytoplasmic actin in postsynaptic structures at the neuromuscular junction.

1981 • 146 citations

Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes.

1981 • 144 citations

A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor-rich sites in Torpedo electroplaques and skeletal muscle.

1987 • 142 citations

The Golgi apparatus remains associated with microtubule organizing centers during myogenesis.

1985 • 141 citations

Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm

1975 • 140 citations

Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation.

1989 • 140 citations

Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.

1991 • 140 citations

Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo.

1986 • 139 citations

Activity-dependent regulation of gene expression in muscle and neuronal cells

1989 • 133 citations

Spatial and temporal expression of acetylcholine receptor RNAs in innervated and denervated rat soleus muscle

1989 • 129 citations

Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly.

1990 • 122 citations

Transmembrane Orientation of Proteins Present in Acetylcholine Receptor‐Rich Membranes from Torpedo marmorata Studied by Selective Proteolysis

1980 • 120 citations

Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.

1981 • 118 citations

Assembly of the mammalian muscle acetylcholine receptor in transfected COS cells.

1991 • 116 citations

Rotational mobility of the membrane‐bound acetylcholine receptor of torpedo electric organ measured by phosphorescence depolarisation

1980 • 113 citations

Peptide extraction by alkaline treatment is accompanied by rearrangement of the membrane‐bound acetylcholine receptor from torpedo marmorata

1980 • 111 citations

Skeletal muscle denervation activates acetylcholine receptor genes.

1989 • 108 citations

Muscle acetylcholine receptor biosynthesis. Regulation by transcript availability.

1987 • 107 citations

Association of the postsynaptic 43K protein with newly formed acetylcholine receptor clusters in cultured muscle cells.

1985 • 107 citations

Receptor stability and channel conversion in the subsynaptic membrane of the developing mammalian neuromuscular junction

1980 • 105 citations

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts.

1990 • 102 citations

Peripheral proteins of postsynaptic membranes from Torpedo electric organ identified with monoclonal antibodies.

1984 • 100 citations

A novel 87,000-Mr protein associated with acetylcholine receptors in Torpedo electric organ and vertebrate skeletal muscle.

1989 • 100 citations

Identification of the mouse muscle 43,000-dalton acetylcholine receptor-associated protein (RAPsyn) by cDNA cloning.

1988 • 98 citations

Cholinergic Receptors at Denervated Mammalian Motor End‐Plates

1975 • 97 citations

Acetylcholine receptors at the neuromuscular junction: Developmental change in receptor turnover

1977 • 96 citations

Denervated endplates have a dual population of junctional acetylcholine receptors

1981 • 95 citations

Extracellular domains mediating ɛ subunit interactions of muscle acetylcholine receptor

1991 • 94 citations

Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis

1988 • 93 citations

The gene and its product

1989 • 93 citations

Distribution of acetylated α‐tubulin in retina and in in vitro—assembled microtubules

1988 • 93 citations

Regulation of surface expression of acetylcholine receptors in response to serum and cell growth in the BC3H1 muscle cell line.

1983 • 92 citations

Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells

1990 • 90 citations

Mutagenesis of the 43-kD postsynaptic protein defines domains involved in plasma membrane targeting and AChR clustering.

1991 • 90 citations

An acetylcholine receptor alpha-subunit promoter conferring preferential synaptic expression in muscle of transgenic mice.

1991 • 88 citations

Association of the Mr 58,000 postsynaptic protein of electric tissue with Torpedo dystrophin and the Mr 87,000 postsynaptic protein.

1992 • 87 citations

Transfer of a Protein Encoded by a Single Nucleus to Nearby Nuclei in Multinucleated Myotubes

1989 • 87 citations

Compartmentalization of cold-stable and acetylated microtubules in the subsynaptic domain of chick skeletal muscle fibre

1990 • 87 citations

The rotational diffusion of the acetylcholine receptor in Torpeda marmorata membrane fragments studied with a spin-labelled alpha-toxin: importance of the 43 000 protein(s).

1982 • 85 citations

Acetylcholine receptor degradation measured by pulse chase labelling

1976 • 85 citations

Phosphorylation in vitro of Membrane Fragments from Torpedo marmorata Electric Organ. Effect on Membrane Solubilization by Detergents

1980 • 85 citations

Denervation increases turnover rate of junctional acetylcholine receptors.

1980 • 82 citations

Nicotinic postsynaptic membranes from Torpedo: sidedness, permeability to macromolecules, and topography of major polypeptides.

1982 • 77 citations

Degradation of junctional and extrajunctional acetylcholine receptors by developing rat skeletal muscle.

1979 • 75 citations

The relationship of the postsynaptic 43K protein to acetylcholine receptors in receptor clusters isolated from cultured rat myotubes.

1987 • 75 citations

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.

1980 • 74 citations

Evolution of cholinergic proteins in developing slow and fast skeletal muscles in chick embryo.

1980 • 74 citations

Regulation of turnover and number of acetylcholine receptors at neuromuscular junctions

1990 • 71 citations

Preferred Microtubules for Vesicle Transport in Lobster Axons

1987 • 71 citations

Assembly of Torpedo acetylcholine receptors in Xenopus oocytes.

1991 • 71 citations

Metabolic stabilization of endplate acetylcholine receptors regulated by Ca2+ influx associated with muscle activity

1991 • 70 citations

Metabolic stabilization of acetylcholine receptors at newly formed neuromuscular junctions in rat

1981 • 69 citations

The microtubule-organizing complex and the Golgi apparatus are co-localized around the entire nuclear envelope of interphase cardiac myocytes

1987 • 69 citations

Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

1989 • 69 citations

Talin is a post-synaptic component of the rat neuromuscular junction

1986 • 67 citations

Skeletal muscle acetylcholine receptor. Purification, characterization, and turnover in muscle cell cultures.

1978 • 67 citations

Expression of acetylcholine receptor alpha-subunit mRNA during differentiation of the BC3H1 muscle cell line.

1984 • 66 citations

Neurotrophic control of channel properties at neuromuscular synapses of rat muscle

1983 • 66 citations

Synthesis and assembly of acetylcholine receptor, a multisubunit membrane glycoprotein

1986 • 65 citations

Dystrophin in Electric Organ of Torpedo californica Homologous to That in Human Muscle

1989 • 63 citations

Protein Phosphorylation of Nicotinic Acetylcholine Receptor

1989 • 63 citations

Factors regulating the susceptibility of the acetylcholine receptor protein to heat inactivation

1979 • 62 citations

Production and characterization of a monoclonal antibody directed against the 43,000-dalton v1 polypeptide from Torpedo marmorata electric organ.

1983 • 61 citations

The subsynaptic 43-kDa protein is concentrated at developing nerve-muscle synapses in vitro.

1985 • 60 citations

The 43 kilodalton protein of Torpedo nicotinic postsynaptic membranes: purification and determination of primary structure

1987 • 59 citations

Asymmetric distribution of dystrophin in developing and adult Torpedo marmorata electrocyte: evidence for its association with the acetylcholine receptor-rich membrane.

1990 • 58 citations

Evidence for a polarity in the distribution of proteins from the cytoskeleton in Torpedo marmorata electrocytes.

1986 • 56 citations

Visualization of the cytoplasmic surface of Torpedo postsynaptic membranes by freeze-etch and immunoelectron microscopy.

1987 • 56 citations

Change in state of phosphorylation of acetylcholine receptor during maturation of the electromotor synapse in Torpedo marmorata electric organ.

1981 • 56 citations

Compartmentalized transcription of acetylcholine receptor genes during motor endplate epigenesis.

1991 • 55 citations

Nucleus-specific translation and assembly of acetylcholinesterase in multinucleated muscle cells.

1990 • 52 citations

Dystrophin is a component of the subsynaptic membrane.

1991 • 52 citations

Acetylcholine receptor alpha-subunit mRNA is increased by ascorbic acid in cloned L5 muscle cells: Northern blot analysis and in situ hybridization.

1989 • 51 citations

Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons.

1988 • 50 citations

Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells.

1987 • 49 citations

Neurotransmission regulates stability of acetylcholine receptors at the neuromuscular junction

1989 • 49 citations

The Regulation of Acetylcholine Receptor Expression in Mammalian Muscle

1983 • 48 citations

Cyclic AMP stabilizes the degradation of original junctional acetylcholine receptors in denervated muscle

1991 • 47 citations

Synthesis of acetylcholine receptor during differentiation of cultured embryonic muscle cells.

1975 • 47 citations

A protein antigenically related to nuclear lamin B mediates the association of intermediate filaments with desmosomes.

1990 • 46 citations

cDNAs for the postsynaptic 43-kDa protein of Torpedo electric organ encode two proteins with different carboxyl termini.

1987 • 45 citations

Degradation rate of acetylcholine receptors inserted into denervated vertebrate neuromuscular junctions.

1989 • 45 citations

Acetylcholine receptor-associated 43K protein contains covalently bound myristate.

1988 • 44 citations

Immunochemical identification of desmin in Torpedo postsynaptic membranes and at the rat neuromuscular junction

1989 • 44 citations

Localization of an Acetylcholine Receptor Intron to the Nuclear Membrane

1990 • 44 citations

Mobility and detergent extractability of acetylcholine receptors on cultured rat myotubes: a correlation.

1983 • 43 citations

Quantitative studies on the localization of the cholinergic receptor protein in the normal and denervated electroplaque from Electrophorus electricus.

1978 • 40 citations

Differential expression of acetylcholine receptor mRNA in nuclei of cultured muscle cells.

1989 • 40 citations

Acetylcholine receptor expression in primary cultures of embryonic chick myotubes—I. Discoordinate regulation of α-, γ- and δ-subunit gene expression by calcitonin gene-related peptide and by muscle electrical activity

1989 • 38 citations

Consequences of denervation on the distribution of the cholinergic (nicotinic) receptor sites fromElectrophorus electricus revealed by high resolution autoradiography

1973 • 37 citations

Formation of acetylcholine receptor clusters in chick myotubes: migration or new insertion?

1989 • 37 citations

Asynchronous assembly of the acetylcholine receptor and of the 43-kD nu1 protein in the postsynaptic membrane of developing Torpedo marmorata electrocyte.

1989 • 35 citations

Metabolic stabilization of acetylcholine receptors in vertebrate neuromuscular junction by muscle activity.

1990 • 35 citations

Serine-specific phosphorylation of nicotinic receptor associated 43K protein

1991 • 35 citations

Localization of mRNAs coding for CMD1, myogenin and the α-subunit of the acetylcholine receptor during skeletal muscle development in the chicken

1992 • 35 citations

On the effect of muscle activity on the end‐plate membrane in denervated mouse muscle.

1989 • 34 citations

Intracellular and surface distribution of a membrane protein (CD8) derived from a single nucleus in multinucleated myotubes.

1989 • 34 citations

Localization of dystrophin and dystrophin-related protein at the electromotor synapse and neuromuscular junction in Torpedo marmorata

1992 • 34 citations

The low molecular weight guanosine triphosphate-binding protein Rab6p associates with distinct post-Golgi vesicles in Torpedo marmorata electrocytes

1992 • 32 citations

Change in desensitization of cat muscle acetylcholine receptor caused by coexpression of Torpedo acetylcholine receptor subunits in Xenopus oocytes.

1989 • 30 citations

Presence of a protein immunologically related to lamin B in the postsynaptic membrane of Torpedo marmorata electrocyte.

1989 • 30 citations

Expression of RNA transcripts for the postsynaptic 43 kDa protein in innervated and denervated rat skeletal muscle

1989 • 29 citations

Nicotinic receptor-associated 43K protein and progressive stabilization of the postsynaptic membrane

1992 • 29 citations

Regulation of acetylcholine receptor synthesis at the level of translation in rat primary muscle cells.

1989 • 28 citations

300-kD subsynaptic protein copurifies with acetylcholine receptor-rich membranes and is concentrated at neuromuscular synapses

1987 • 28 citations

Inhibition of acetylcholine receptor assembly by activity in primary cultures of embryonic rat muscle cells.

1986 • 26 citations

Developmental expression of the 43K and 58K postsynaptic membrane proteins and nicotinic acetylcholine receptors in Torpedo electrocytes

1990 • 26 citations

Compartmentalization of Acetylcholine Receptor Gene Expression during Development of the Neuromuscular Junction

1990 • 25 citations

Localization of surface and internal acetylcholine receptors in developing fast and slow muscles of the chick embryo

1981 • 21 citations

Uptake of horseradish peroxidase in denervated skeletal muscle occurs primarily at the endplate region

1984 • 21 citations

Cytoplasmic components of acetylcholine receptor clusters of cultured rat myotubes: the 58-kD protein.

1991 • 19 citations

Biological implications of microtubule dynamics.

1987 • 15 citations

Organization and dynamics of microtubules in Torpedo marmorata electrocyte: Selective association with specialized domains of the postsynaptic membrane

1991 • 14 citations

Development of the electromotor system of Torpedo marmorata: Distribution of extracellular matrix and cytoskeletal components during acetylcholine receptor focalization

1987 • 10 citations

Developmental changes in the subcellular distribution of the 43K (v1) polypeptides in Torpedo marmorata electrocyte: support for a role in acetylcholine receptor stabilization

1991 • 9 citations

The Torpedo Electrocyte: A Model System for the Study of Receptor-Cytoskeleton Interactions

1987 • 6 citations