Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.

Liver Regeneration

1997 • 2,731 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase

1992 • 625 citations

Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation

1994 • 573 citations

The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

1977 • 563 citations

Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I

1996 • 540 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Cell lineages and oval cell progenitors in rat liver development.

1991 • 391 citations

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

1991 • 387 citations

Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.

1991 • 376 citations

Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice.

1993 • 348 citations

Hepatic stem cells in liver regeneration

1996 • 308 citations

Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

1995 • 304 citations

Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure.

1982 • 295 citations

The liver as a stem cell and lineage system

1992 • 237 citations

Histochemical staining of clonal mammalian cell lines expressingE. coli ? galactosidase indicates heterogeneous expression of the bacterial gene

1987 • 232 citations

Complete reconstitution of mouse liver with xenogeneic hepatocytes.

1995 • 217 citations

Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment.

1993 • 185 citations

Self-induced correction of the genetic defect in tyrosinemia type I.

1994 • 170 citations

THE FATE OF SERIALLY TRANSPLANTED BONE MARROW CELL POPULATIONS FROM YOUNG AND OLD DONORS

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Liver stem cells.

1994 • 116 citations

Different molecular basis for fumarylacetoacetate hydrolase deficiency in the two clinical forms of hereditary tyrosinemia (type I).

1990 • 98 citations

Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.

1992 • 97 citations

Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver.

1988 • 85 citations

Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1.

1993 • 73 citations

Retroviral-Mediated Gene Transfer of Human Ornithine Transcarbamylase into Primary Hepatocytes of spf and spf-ash Mice

1992 • 57 citations

Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

1988 • 47 citations

[Capacity of regeneration in liver epithelia of juvenile, repeated partially hepatectomized rats. Autoradiographic studies after continous infusion of 3H-thymidine (author's transl)].

1973 • 36 citations

Accelerated aging of dermal fibroblast-like cells from senescence-accelerated mouse (SAM). 1. Acceleration of population aging in vitro

1994 • 30 citations

Localization of cells in the rat brain expressing fumarylacetoacetate hydrolase, the deficient enzyme in hereditary tyrosinemia type 1

1993 • 23 citations

Inherited Hepatic Enzyme Defects as Candidates for Liver-Directed Gene Therapy

1991 • 20 citations

IN SITU HYBRIDIZATION UTILIZING A Y CHROMOSOME DNA PROBE

1995 • 11 citations