Regulation of Cell Growth and Transformation by the Epidermal Growth Factor Receptor

Epidermal Growth Factor

1979 • 2,964 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Recycling receptors: The round-trip itinerary of migrant membrane proteins

1983 • 780 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains

1985 • 453 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

1985 • 301 citations

Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.

1982 • 271 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Regulation of Cell Proliferation by Epidermal Growth Factor

1983 • 235 citations

Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

1985 • 232 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor

1985 • 216 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

1986 • 167 citations

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

1985 • 98 citations

Large deletions in the cytoplasmic kinase domain of the epidermal growth factor receptor do not affect its laternal mobility.

1986 • 97 citations

Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase.

1985 • 47 citations

EGF growth promoting activity is neutralized by phorbol esters

1980 • 18 citations