Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Proteoglycans in Cell Regulation

1989 • 691 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

Cell surface heparan sulfate proteoglycans.

1992 • 476 citations

Integral membrane heparan sulfate proteoglycans

1993 • 423 citations

Betacellulin: a mitogen from pancreatic beta cell tumors

1993 • 392 citations

Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

1993 • 365 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.

1988 • 355 citations

Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) and endo-β-<scp>d</scp>-galactosidase (keratanase)

1980 • 292 citations

Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

1991 • 260 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

1991 • 236 citations

Tumor Formation Dependent on Proteoglycan Biosynthesis

1988 • 217 citations

Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas.

1992 • 184 citations

Induction and expression of amphiregulin in human pancreatic cancer.

1994 • 160 citations

Structure, expression and function of a schwannoma-derived growth factor

1990 • 153 citations

Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin.

1994 • 152 citations

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon.

1992 • 151 citations

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.

1993 • 138 citations

Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors.

1992 • 137 citations

Expression of transforming growth factor α, amphiregulin and cripto-1 in human breast carcinomas

1994 • 117 citations

Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells.

1994 • 107 citations

Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: Nuclear localization of endogenous amphiregulin

1991 • 99 citations

Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity.

1993 • 93 citations

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer.

1993 • 90 citations

Identification of heparan sulfate proteoglycan as a high affinity receptor for acidic fibroblast growth factor (aFGF) in a parathyroid cell line.

1991 • 86 citations

Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells

1992 • 81 citations

Adenosine triphosphate sulfurylase from Penicillium chrysogenum: Equilibrium binding, substrate hydrolysis, and isotope exchange studies

1978 • 81 citations

Identification of a lipid-anchored heparan sulfate proteoglycan in Schwann cells.

1990 • 69 citations

The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

1990 • 66 citations

Purification of heparinase and heparitinase by affinity chromatography on glycosaminoglycan-bound ah-sepha-rose 4b

1981 • 55 citations

Expression of Amphiregulin, a Novel Gene of the Epidermal Growth Factor Family, in Human Gastric Carcinomas

1993 • 45 citations

The Interaction of Amphiregulin with Nuclei and Putative Nuclear Localization Sequence Binding Proteins

1992 • 44 citations

Characterization of high and low molecular weight forms of amphiregulin that differ in glycosylation and peptide core length. Evidence that the NH2-terminal region is not critical for bioactivity.

1993 • 36 citations

IMMUNOHISTOCHEMICAL DETECTION OF CRIPTO-1, AMPHIREGULIN AND TRANSFORMING GROWTH-FACTOR-ALPHA IN HUMAN GASTRIC CARCINOMAS AND INTESTINAL METAPLASIAS

1994 • 24 citations

Leakey Leaves Kenya Museums

1989 • 3 citations

Leakey Leaves Kenya Museums

1989 • 2 citations