Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells.

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Transforming growth factor α

1988 • 707 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

1991 • 260 citations

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

1991 • 247 citations

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

1991 • 236 citations

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon.

1992 • 151 citations

Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.

1993 • 138 citations

Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors.

1992 • 137 citations

Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.

1987 • 130 citations

Transforming growth factor‐α

1990 • 126 citations

Basic Fibroblast Growth Factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes

1993 • 116 citations

Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation.

1990 • 109 citations

Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity.

1993 • 93 citations

Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer.

1993 • 90 citations

Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line.

1992 • 84 citations

Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells

1992 • 81 citations

c‐erbB‐2 and ras expression levels in breast cancer are correlated and show a co‐operative association with unfavorable clinical outcome

1991 • 74 citations

Intracrine regulation at the nucleus–a further mechanism of growth factor activity?

1990 • 71 citations

Regulation by Estrogen through the 5′-Flanking Region of the Transforming Growth Factor α Gene

1991 • 69 citations

A Heparin Sulfate-Regulated Human Keratinocyte Autocrine Factor Is Similar or Identical to Amphiregulin

1991 • 61 citations

Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor

1990 • 60 citations

Expression of transforming growth factor alpha (TGFα) in breast cancer

1991 • 53 citations

The Interaction of Amphiregulin with Nuclei and Putative Nuclear Localization Sequence Binding Proteins

1992 • 44 citations

Expression of p21ras gene products in breast cancer relates to histological types and to receptor and nodal status

1988 • 23 citations

The role of ras gene expression and transforming growth factor α production in the etiology and progression of rodent and human breast cancer

1991 • 9 citations