Transforming Growth Factor-ß1 and Prostate Cancer

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

Derivation of androgen‐independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells

1994 • 484 citations

Cancer in the European community and its member states

1990 • 475 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 AND TRANSFORMING GROWTH FACTOR-beta 1 IN PATIENTS WITH METASTATIC PROSTATIC CARCINOMA

1999 • 379 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1995 • 340 citations

Antagonistic effect of androgen on prostatic cell death

1984 • 339 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Mad-related genes in the human

1996 • 308 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

1992 • 242 citations

Identification of a Cellular Receptor for Transforming Growth Factor-β in Rat Ventral Prostate and Its Negative Regulation by Androgens*

1988 • 178 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Transforming growth factor-? in benign and malignant prostate

1999 • 156 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.

1999 • 147 citations

Induction of Smooth Muscle Cell Phenotype in Cultured Human Prostatic Stromal Cells

1997 • 127 citations

Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines.

1996 • 118 citations

Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells.

1998 • 117 citations

Transforming Growth Factor-β Signaling in Epithelial Cells

1997 • 113 citations

Transforming growth factor-beta 1: comparative immunohistochemical localization in human primary and metastatic prostate cancer.

1995 • 108 citations

Stromal cells of the human prostate: Initial isolation and characterization

1996 • 105 citations

Transforming growth factor β 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients

1996 • 104 citations

Changes in gene expression of growth factors and their receptors during castration-induced involution and androgen-induced regrowth of rat prostates

1996 • 100 citations

Prostatic ductal system in rats: Regional variation in stromal organization

1996 • 97 citations

Osteoblast conditioned media contain TGF-?1 and modulate the migration of prostate tumor cells and their interactions with extracellular matrix components

1999 • 92 citations

Transdifferentiation of NRP-152 rat prostatic basal epithelial cells toward a luminal phenotype: regulation by glucocorticoid, insulin-like growth factor-I and transforming growth factor-beta

1999 • 87 citations

Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis.

1994 • 84 citations

Reduced levels of transforming growth factor beta receptor type II in human prostate cancer: an immunohistochemical study.

1996 • 84 citations

Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta

1988 • 80 citations

Prostate epithelial differentiation is dictated by its surrounding stroma

1996 • 80 citations

Modulation of transforming growth factor beta 1 effects on prostate cancer cell proliferation by growth factors and extracellular matrix.

1995 • 78 citations

Developmental and Hormonal Regulation of Transforming Growth Factor-β1 (TGFβ1), -2, and -3 Gene Expression in Isolated Prostatic Epithelial and Stromal Cells: Epidermal Growth Factor and TGFβ Interactions¹

1998 • 77 citations

Role of androgen in prostate growth and regression: Stromal-epithelial interaction

1996 • 72 citations

Transforming growth factor β1 as a biomarker for prostate cancer

1992 • 71 citations

Treatment of Advanced Prostatic Cancer

1987 • 66 citations

Prostatic ductal system in rats: Tissue-specific expression and regional variation in stromal distribution of transforming growth factor-β1

1997 • 58 citations

Plasmin, Substilisin-like Endoproteases, Tissue Plasminogen Activator, and Urokinase Plasminogen Activator Are Involved in Activation of Latent TGF-β1in Human Seminal Plasma

1998 • 53 citations

Mechanisms of TGF-β-Induced Cell Cycle Arrest

1998 • 52 citations

Transforming Growth Factor-β1 Induces Nuclear to Cytoplasmic Distribution of Androgen Receptor and Inhibits Androgen Response in Prostate Smooth Muscle Cells¹

1998 • 46 citations

SERUM PSA AFTER ANTIANDROGEN THERAPY

1993 • 46 citations

Transforming Growth Factor-β1 (TGFβ1) Enhances Apoptosis in Human Papillomavirus Type 16-Immortalized Human Ectocervical Epithelial Cells

1995 • 38 citations

Growth factors in expressed prostatic fluid from men with prostate cancer, BPH, and clinically normal prostates

1999 • 28 citations

Induction of apoptosis by transforming growth factor beta 1 in glioma and trigeminal neurinoma cells.

1994 • 24 citations

Insensitivity to growth inhibition by TGF-β1 correlates with a lack of inhibition of the CDK2 activity in prostate carcinoma cells

1998 • 22 citations

Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities

1995 • 15 citations

Prostate cancer cells lose their sensitivity to TGFβI growth inhibition with tumor progression

1995 • 12 citations