Transforming Growth Factor-β1 Induces Nuclear to Cytoplasmic Distribution of Androgen Receptor and Inhibits Androgen Response in Prostate Smooth Muscle Cells¹

LNCaP model of human prostatic carcinoma.

1983 • 1,749 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Immunohistochemical Localization of the Androgen Receptor in Rat and Human Tissues*

1990 • 492 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

Androgen Receptor Localization in Different Cell Types of the Adult Rat Prostate*

1991 • 446 citations

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

1992 • 430 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: A stem cell model

1996 • 409 citations

Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers

1989 • 329 citations

Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate

1994 • 323 citations

Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.

1992 • 279 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Androgen Receptor Expression in Developing Male Reproductive Organs*

1991 • 244 citations

Stromal-epithelial interactions—I. Induction of prostatic phenotype in urothelium of testicular feminized (Tfm/y) mice

1981 • 227 citations

Intracellular Localization of the Glucocorticoid Receptor: Evidence for Cytoplasmic and Nuclear Localization*

1987 • 197 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Smooth Muscle-Epithelial Interactions in Normal and Neoplastic Prostatic Development

1996 • 191 citations

The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.

1995 • 185 citations

Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation.

1994 • 185 citations

Identification of a Cellular Receptor for Transforming Growth Factor-β in Rat Ventral Prostate and Its Negative Regulation by Androgens*

1988 • 178 citations

Identification of three proline-directed phosphorylation sites in the human androgen receptor.

1995 • 174 citations

Antipeptide Antibodies to Two Distinct Regions of the Androgen Receptor Localize the Receptor Protein to the Nuclei of Target Cells in the Rat and Human Prostate*

1990 • 173 citations

Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues.

1996 • 167 citations

Bidirectional transport of glucocorticoid receptors across the nuclear envelope.

1993 • 167 citations

Stromal‐epithelial interactions: II. Regulation of prostatic growth by embryonic urogenital sinus mesenchyme

1983 • 166 citations

Differential effects of transforming growth factor β on human prostate cancer cells in vitro

1989 • 166 citations

Androgen‐dependent growth regulation of and release of specific protein(s) by the androgen receptor containing human prostate tumor cell line LNCaP

1986 • 137 citations

Vascular Smooth Muscle Cells as Target for Estrogen

1993 • 131 citations

Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus.

1995 • 131 citations

Down-regulation of protein and mRNA expression for transforming growth factor-β (TGF-β1) type I and type II receptors in human prostate cancer

1997 • 130 citations

Expression of transforming growth factor-beta 1 in prostate cancer.

1994 • 128 citations

Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement.

1993 • 106 citations

Estrogen synthesis, estrogen metabolism, and functional estrogen receptors in rat arterial smooth muscle cells in culture.

1995 • 98 citations

The Effects of Growth Factors Associated with Osteoblasts on Prostate Carcinoma Proliferation and Chemotaxis: Implications for the Development of Metastatic Disease*

1997 • 95 citations

Androgen Receptor Activation in Prostatic Tumor Cell Lines by Insulin-Like Growth Factor-1, Keratinocyte Growth Factor and Epidermal Growth Factor

1995 • 88 citations

Growth factor regulation of gene expression in the human prostatic carcinoma cell line LNCaP.

1993 • 85 citations

Reduced levels of transforming growth factor beta receptor type II in human prostate cancer: an immunohistochemical study.

1996 • 84 citations

Effects of mitogens on androgen receptor-mediated transactivation.

1996 • 83 citations

The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor.

1994 • 82 citations

Regulation of growth of LNCaP human prostate tumor cells by growth factors and steroid hormones

1991 • 81 citations

Expression and localization of transforming growth factor-beta receptors type I and type II in the rat ventral prostate during regression

1996 • 74 citations

Molecular Cloning and Expression of ps20 Growth Inhibitor

1998 • 70 citations

Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules

1995 • 65 citations

Androgen receptor expression and 5 alpha-reductase activity along the proximal-distal axis of the rat prostatic duct.

1992 • 61 citations

Purification of a Novel Protein (ps20) from Urogenital Sinus Mesenchymal Cells with Growth Inhibitory Properties in Vitro

1995 • 51 citations

Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons.

1992 • 49 citations

Modulation of Sensitivity to Transforming Growth Factor-β1 (TGF-β1) and the Level of Type II TGF-β Receptor in LNCaP Cells by Dihydrotestosterone

1996 • 45 citations

Localization of Transforming Growth Factor-β₁ and Type II Receptor in Developing Normal Human Prostate and Carcinoma Tissues

1998 • 40 citations

Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1).

1996 • 39 citations

Characterization of a fetal urogenital sinus mesenchymal cell line U4F: Secretion of a negative growth regulatory activity

1992 • 35 citations

Effects of Interferon β ser and Transforming Growth Factor β on Prostatic Cell Lines

1991 • 35 citations

Responses of NBT-II bladder carcinoma cells to conditioned medium from normal fetal urogenital sinus.

1987 • 31 citations

Proliferation of a highly androgen-sensitive ductus deferens cell line (DDT1MF-2) is regulated by glucocorticoids and modulated by growth on collagen

1983 • 29 citations

Characterization of the hamster DDT‐1 cell aFGF/HGBF‐I gene and cDNA and its modulation by steroids

1990 • 22 citations

Transforming growth factor-beta1 (TGF-beta1) in penile and prostate growth in the rat during sexual maturation.

1998 • 17 citations

Isolation and characterization of a novel human prostatic stromal cell culture: DuK50

1995 • 16 citations

Acidic fibroblast growth factor gene 5′ non‐coding exon and flanking region from hamster DDT1 cells: Identification of the promoter region and transcriptional regulation by testosterone and aFGF protein

1993 • 14 citations

Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells

1996 • 12 citations