Regulation of Mre11/Rad50 by Nbs1

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Structural Biology of Rad50 ATPase

2000 • 900 citations

The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

1998 • 887 citations

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

2002 • 857 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

Molecular Architecture of SMC Proteins and the Yeast Cohesin Complex

2002 • 718 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

1990 • 591 citations

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences

1986 • 575 citations

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

2002 • 547 citations

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1999 • 533 citations

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

2002 • 511 citations

Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

2001 • 508 citations

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

2001 • 493 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

2000 • 484 citations

A genetic study of X-ray sensitive mutants in yeast

1974 • 478 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

1998 • 410 citations

The Many Interfaces of Mre11

1998 • 401 citations

The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

2002 • 395 citations

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

2002 • 306 citations

Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes

2001 • 294 citations

Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.

1995 • 269 citations

The Mre11-Rad50-Xrs2 Protein Complex Facilitates Homologous Recombination-Based Double-Strand Break Repair in Saccharomyces cerevisiae

1999 • 267 citations

Distinct roles of two separablein vitroactivities of yeast Mre11 in mitotic and meiotic recombination

1998 • 266 citations

The yeast Xrs2 complex functions in S phase checkpoint regulation

2001 • 225 citations

The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA

1998 • 224 citations

Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae.

1993 • 218 citations

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

2001 • 214 citations

XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination.

1992 • 207 citations

A Murine Model of Nijmegen Breakage Syndrome

2002 • 206 citations

Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

2001 • 192 citations

A mechanistic basis for Mre11-directed DNA joining at microhomologies

2000 • 191 citations

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

2001 • 186 citations

Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA

2002 • 178 citations

The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity

2001 • 159 citations

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

1997 • 135 citations

RAD50 protein ofS.cerevisiaeexhibits ATP-dependent DNA binding

1993 • 124 citations

Mre11 and Rad50 from Pyrococcus furiosus : Cloning and Biochemical Characterization Reveal an Evolutionarily Conserved Multiprotein Machine

2000 • 124 citations

Structure of the Rad50·Mre11 DNA Repair Complex fromSaccharomyces cerevisiae by Electron Microscopy

2001 • 115 citations

Equal Sister Chromatid Exchange Is a Major Mechanism of Double-Strand Break Repair in Yeast

2003 • 104 citations

Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation

2003 • 76 citations

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

2002 • 70 citations

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP

2002 • 68 citations

Stoichiometry and thermodynamics of the interaction between the Fc fragment of human IgG1 and its low-affinity receptor Fc.gamma.RIII

1995 • 58 citations