Chromosomal Loop Organization in Eukaryotic Genomes

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

The Genetics and Biology of Drosophila

1976 • 1,427 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

The structure of histone-depleted metaphase chromosomes

1977 • 1,083 citations

Identification of a nuclear protein matrix

1974 • 1,016 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

On the structure of the folded chromosome of Escherichia coli

1972 • 635 citations

Supercoiled loops and eucaryotic DNA replication

1980 • 626 citations

Gene gating: a hypothesis.

1985 • 599 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster

1976 • 556 citations

Metaphase chromosome structure

1986 • 538 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

A glimpse at chromosomal order

1987 • 423 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

1988 • 415 citations

Higher order metaphase chromosome structure: Evidence for metalloprotein interactions

1982 • 398 citations

The effect of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene

1983 • 368 citations

The organisation of chromatin loops: characterization of a scaffold attachment site

1986 • 308 citations

The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain.

1988 • 280 citations

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants

1988 • 277 citations

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments

1982 • 271 citations

Conformational constraints in nuclear dna

1976 • 257 citations

A consensus sequence for cleavage by vertebrate DNA topoisomerase II

1988 • 253 citations

Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold

1988 • 251 citations

The metaphase scaffold is helically folded: Sister chromatids have predominantly opposite helical handedness

1988 • 232 citations

Mapping replication units in animal cells

1989 • 232 citations

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

1987 • 229 citations

Nuclear scaffold attachment sites in the human globin gene complexes.

1988 • 225 citations

Visualization of a filamentous nucleoskeleton with a 23 nm axial repeat.

1988 • 216 citations

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1989 • 206 citations

Localization of DNAase I-sensitive sequences to specific regions of interphase nuclei

1985 • 197 citations

RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML

1989 • 184 citations

Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells.

1988 • 177 citations

Chromatin domain surrounding the human interferon-.beta. gene as defined by scaffold-attached regions

1988 • 169 citations

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

1988 • 168 citations

DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.

1988 • 154 citations

Interaction of DNA with nuclear scaffolds in vitro

1988 • 143 citations

Review Lecture: Mechanisms and evolutionary origins of variable X-chromosome activity in mammals

1974 • 140 citations

Scaffold attachment of DNA loops in metaphase chromosomes

1988 • 137 citations

Chromosomal loop anchorage sites appear to be evolutionarily conserved

1986 • 121 citations

Immunoglobulin κ gene expression after stable integration

1989 • 120 citations

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.

1989 • 116 citations

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

1987 • 113 citations

A hotspot for novel amplification joints in a mosaic of Alu-like repeats and palindromic A + T-rich DNA.

1987 • 111 citations

Anchorage of the Chinese hamster dihydrofolate reductase gene to the nuclear scaffold occurs in an intragenic region

1987 • 99 citations

Immunoglobulin κ gene expression after stable integration

1989 • 81 citations

Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome

1986 • 81 citations

Yeast ARS function and nuclear matrix association coincide in a short sequence from the human HPRT locus

1988 • 71 citations

Bent DNA is a structural feature of scaffold-attached regions in Drosophila melanogaster interphase nuclei

1989 • 70 citations

Protein:DNA interactions at chromosomal loop attachment sites

1989 • 68 citations

Mitotic architecture of the cell: the filament networks of the nucleus and cytoplasm.

1983 • 60 citations

Supercoiled loops and the organization of replication and transcription in eukaryotes

1985 • 57 citations

Sequence dependence of Drosophila topoisomerase II in plasmid relaxation and DNA binding

1987 • 54 citations

Structural analysis of a rabbit immunoglobulinx2 J-C locus reveals multiple deletions

1983 • 52 citations

Molecular characterization of a beta zero-thalassemia resulting from a 1.4 kilobase deletion

1988 • 51 citations

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

1990 • 47 citations

On the Molecular Basis of Transvection Effects and the Regulation of Transcription

1985 • 46 citations

The ultrastructure of upstream and downstream regions of an active Balbiani ring gene

1989 • 43 citations

Expression of the Drosophila type II topoisomerase is developmentally regulated

1988 • 43 citations

Chromosomal loop/nuclear matrix organization of transcriptionally active and inactive RNA polymerases in HeLa nuclei

1988 • 34 citations

Evolution of the immunoglobulin kappa light chain locus in the rabbit: evidence for differential gene conversion events.

1986 • 33 citations

Stable DNA-protein complexes in eukaryotic chromatin

1987 • 33 citations

Identification of attachment proteins for DNA in Chinese hamster ovary cells.

1988 • 29 citations

Chromatin loop structure of the human X chromosome: relevance to X inactivation and CpG clusters.

1989 • 20 citations

The association of the interspersed repetitive KpnI sequences with the nuclear matrix.

1985 • 18 citations

Constitutive Attachment of Murine Erythroleukemia Cell Histone-Depleted DNA Loops to Nuclear Scaffolding Is Found in the β-Major but Not the α1-Globin Gene

1988 • 16 citations

An Active Chromatin Structure Acquired by Translocated c-myc Genes

1986 • 15 citations

An active chromatin structure acquired by translocated c-myc genes.

1986 • 7 citations