Genetic determinants of pancreatic ε-cell development

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

2002 • 1,500 citations

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

2000 • 1,416 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1997 • 779 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Ghrelin Is Present in Pancreatic α-Cells of Humans and Rats and Stimulates Insulin Secretion

2002 • 573 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

Opposing actions of Arx and Pax4 in endocrine pancreas development

2003 • 565 citations

Handbook of Physiology. Section- 2

1967 • 520 citations

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas

2000 • 513 citations

Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

2002 • 458 citations

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas

2002 • 449 citations

Handbook of Physiology Section 7: Endocrinology

1976 • 448 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development

2004 • 442 citations

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1993 • 371 citations

Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors

2002 • 347 citations

Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity

2002 • 276 citations

Identification and characterization of a novel gastric peptide hormone: The motilin-related peptide

2000 • 233 citations

Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells

2004 • 210 citations

mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription Factor

1996 • 210 citations

Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor

1994 • 189 citations

Foxa2 is required for the differentiation of pancreatic α-cells

2004 • 189 citations

The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation

2003 • 145 citations

Pax 4 and 6 regulate gastrointestinal endocrine cell development

1998 • 134 citations

MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas

1997 • 134 citations

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity

2004 • 91 citations

Defining the cell lineages of the islets of Langerhans using transgenic mice.

2002 • 55 citations