The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

Influence of PAX6 Gene Dosage on Development: Overexpression Causes Severe Eye Abnormalities

1996 • 435 citations

Association Between X-Linked Mixed Deafness and Mutations in the POU Domain Gene POU3F4

1995 • 421 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia

2001 • 186 citations

Targeted Mutagenesis of the POU-Domain GeneBrn4/Pou3f4Causes Developmental Defects in the Inner Ear

1999 • 176 citations

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

2001 • 166 citations

Activation of Proglucagon Gene Transcription Through a Novel Promoter Element by the Caudal-Related Homeodomain Protein cdx-2/3

1996 • 134 citations

Glucagon Gene Transcription Activation Mediated by Synergistic Interactions of pax-6 and cdx-2 with the p300 Co-activator

1999 • 127 citations

Pax genes and their role in organogenesis.

1999 • 118 citations

POU Domain Transcription Factor brain 4 Confers Pancreatic α-Cell-Specific Expression of the Proglucagon Gene Through Interaction with a Novel Proximal Promoter G1 Element

1997 • 94 citations

Interaction of Maf Transcription Factors with Pax-6 Results in Synergistic Activation of the Glucagon Promoter

2001 • 81 citations

The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6

2002 • 78 citations

Abrogation of Protein Convertase 2 Activity Results in Delayed Islet Cell Differentiation and Maturation, Increased α-Cell Proliferation, and Islet Neogenesis

2003 • 63 citations

Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer

1999 • 62 citations

Brn-4 Transcription Factor Expression Targeted to the Early Developing Mouse Pancreas Induces Ectopic Glucagon Gene Expression in Insulin-producing β Cells

2002 • 60 citations

The Caudal Homeobox Protein cdx-2/3 Activates Endogenous Proglucagon Gene Expression in InR1-G9 Islet Cells

1997 • 47 citations

Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1‐element

1999 • 37 citations

Molecular genetics of the Pax gene family

1992 • 37 citations

Foxa3 (HNF-3γ) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression

2002 • 27 citations

Mouse mutations and human disorders are paired

1992 • 16 citations