FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

1993 • 827 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain.

1981 • 589 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

Flt3 ligand induces tumor regression and antitumor immune responses in vivo

1997 • 315 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Hematologic effects of flt3 ligand in vivo in mice

1996 • 272 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

Role of human natural killer cells in health and disease

1994 • 179 citations

The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.

1995 • 175 citations

In vivo natural reactivity of mice against tumor cells

1980 • 174 citations

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells

1995 • 159 citations

Expansion of Functional NK Cells in Multiple Tissue Compartments of Mice Treated with Flt3-Ligand: Implications for Anti-Cancer and Anti-Viral Therapy

1998 • 124 citations

Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model.

1997 • 117 citations

ISOLATION, PHENOTYPE, AND ALLOSTIMULATORY ACTIVITY OF MOUSE LIVER DENDRITIC CELLS

1994 • 110 citations

FLT3 ligand administration inhibits tumor growth in murine melanoma and lymphoma.

1998 • 103 citations

Getting to the Source: Dendritic Cells as Therapeutic Reagents for the Treatment of Patients With Cancer

1997 • 95 citations

Molecular mechanisms underlying IFN-_γ-mediated tumor growth inhibition induced during tumor growth inhibition induced during tumor immunotherapy with rIL-12

1996 • 92 citations

Interleukin-12 an integral cytokine in the immune response

1996 • 89 citations

Cytokine Gene Therapy of Cancer Using Interleukin‐12: Murine and Clinical Trials

1996 • 72 citations

lnterleukin-12

1995 • 72 citations

End results of simultaneous splenectomy in patients undergoing total gastrectomy for gastric carcinoma

1996 • 68 citations

IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells.

1996 • 65 citations

Antitumor Activities of IL-12 and Mechanisms of Action

1997 • 54 citations

Induction of Dendritic Cells (DC) by Flt3 Ligand (FL) Promotes the Generation of Tumor-Specific Immune Responses In Vivo

1998 • 52 citations

Effect of splenectomy in tumor-bearing mice and gastric cancer patients.

1977 • 46 citations

Splenectomy, suppressor cell activity, and survival in tumor bearing rats

1980 • 28 citations

The spleen as a source of nonspecific suppressor cells in the tumor-bearing mouse

1980 • 14 citations

FLT3-LIGAND INHIBITS TUMOR PROGRESSION IN MURINE MODEL

1996 • 3 citations