Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

1991 • 598 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

Plasticity of Hippocampal Circuitry in Alzheimer's Disease

1985 • 457 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Acetylcholine and memory

1993 • 421 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

1992 • 324 citations

Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain.

1984 • 312 citations

Individual differences in the cognitive and neurobiological consequences of normal aging

1992 • 287 citations

Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents

1983 • 278 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.

1993 • 247 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease

1983 • 194 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

1991 • 145 citations

Binding sites for [3H]AF-DX 116 and effect of AF-DX 116 on endogenous acetylcholine release from rat brain slices

1989 • 115 citations

Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol

1989 • 115 citations

Physostigmine restores3H-acetylcholine efflux from Alzheimer brain slices to normal level

1986 • 114 citations

Interaction acetylcholine-glutamate in rat hippocampus: involvement of two subtypes of M-2 muscarinic receptors.

1989 • 108 citations

Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?

1987 • 101 citations

Rat hippocampal muscarinic autoreceptors are similar to the M₂ (cardiac) subtype: comparison with hippocampal M₁, atrial M₂ and ileal M₃ receptors

1990 • 101 citations

Multiple-Dose Arecoline Infusions in Alzheimer's Disease

1988 • 99 citations

Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey

1992 • 96 citations

Methods for the analysis of inositol phosphates

1989 • 89 citations

Hippocampal 3H-CPP binding and spatial learning deficits in aged rats

1990 • 81 citations

The Potential for Muscarinic Receptor Subtype-Specific Pharmacotherapy for Alzheimer's Disease

1991 • 77 citations

Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

1993 • 73 citations

Autoradiographic Imaging of Phosphoinositide Turnover in the Brain

1990 • 71 citations

Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze

1989 • 69 citations

Effects of selected muscarinic cholinergic antagonists on [3H]acetylcholine release from rat hippocampal slices.

1988 • 65 citations

Therapeutic potential of CNS-active M2 antagonists: Novel structures and pharmacology

1993 • 64 citations

Characterization and autoradiographic distribution of hemicholinium‐3 high‐affinity choline uptake sites in mammalian brain

1987 • 57 citations

Stimulation of Inositol Phospholipid Breakdown in Rat Cortical and Hippocampal Miniprisms by Noradrenaline, 5‐Hydroxytryptamine and Carbachol: Some Methodological Aspects

1987 • 54 citations

Muscarinic Receptor Subtypes

1990 • 49 citations

Increased responsiveness of the cerebral cortical phosphatidylinositol system to noradrenaline and carbachol in senescent rats

1989 • 48 citations

Endogenous aspartate release in the rat hippocampus is inhibited by M2 ‘cardiac’ muscarinic receptors

1990 • 45 citations

Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions

1994 • 41 citations

Increases in choline levels in rat brain elicited by meclofenoxate

1982 • 38 citations

Characterization of BIBN 99: A lipophilic and selective muscarinic M2 receptor antagonist

1993 • 37 citations

Alzheimer's Disease: a Cell Biological Perspective

1992 • 34 citations

Compensatory changes of in vivo acetylcholine and noradrenaline release in the hippocampus after partial deafferentation, as monitored by microdialysis

1993 • 31 citations

Neurochemical Deficits in Pathological Brain Aging: Specificity and Possible Relevance for Treatment Strategies

1990 • 26 citations

Choline acetyltransferase

1978 • 18 citations

Treatment of Alzheimer's Disease: Hopes and Reality

1991 • 15 citations

New Perspectives on Alzheimer's Disease

1986 • 12 citations

121 EVIDENCE FOR HIGH AFFINITY CHOLINE TRANSPORT IN SYNAPTOSOMES PREPARED FROM HIPPOCAMPUS AND NEOCORTEX OF PATIENTS WITH ALZHEIMERʼS DISEASE

1983 • 3 citations