Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor.

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Emerging Multipotent Aspects of Hepatocyte Growth Factor

1996 • 662 citations

Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure.

1988 • 657 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.

1995 • 578 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Purification and subunit structure of hepatocyte growth factor from rat platelets

1987 • 557 citations

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

2000 • 432 citations

Functional analysis of secreted and transmembrane proteins critical to mouse development

2001 • 404 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

1993 • 379 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

1994 • 363 citations

Hepatocyte Growth Factor (HGF) as a Tissue Organizer for Organogenesis and Regeneration

1997 • 363 citations

Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells

2000 • 335 citations

Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

2002 • 321 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit.

1995 • 281 citations

Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor

1997 • 271 citations

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

2002 • 269 citations

Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

1999 • 254 citations

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

1995 • 248 citations

Purification and Characterization of a Complex Containing Matriptase and a Kunitz-type Serine Protease Inhibitor from Human Milk

1999 • 243 citations

Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like Activity

1999 • 223 citations

Proteolytic activation of hepatocyte growth factor in response to tissue injury.

1994 • 221 citations

Activation of Hepatocyte Growth Factor in the Injured Tissues Is Mediated by Hepatocyte Growth Factor Activator

1996 • 221 citations

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.

1992 • 211 citations

Activation of the zymogen of hepatocyte growth factor activator by thrombin.

1993 • 206 citations

Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas

1996 • 193 citations

Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo

2001 • 188 citations

Purification and Cloning of Hepatocyte Growth Factor Activator Inhibitor Type 2, a Kunitz-type Serine Protease Inhibitor

1997 • 188 citations

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.

2002 • 186 citations

Reversion of Human Glioblastoma Malignancy by U1 Small Nuclear RNA/Ribozyme Targeting of Scatter Factor/Hepatocyte Growth Factor and c-met Expression

1999 • 181 citations

Activation of Hepatocyte Growth Factor by two Homologous Proteases, Blood-Coagulation Factor XIIa and Hepatocyte Growth Factor Activator

1995 • 172 citations

Prometastatic Effect ofN-Acetylglucosaminyltransferase V Is Due to Modification and Stabilization of Active Matriptase by Adding β1–6 GlcNAc Branching

2002 • 172 citations

Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity.

1994 • 171 citations

Regulation of the activity of matriptase on epithelial cell surfaces by a blood‐derived factor

2001 • 139 citations

Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture.

1995 • 138 citations

Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma.

2000 • 128 citations

Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Specific Cell Surface Binding Protein of Hepatocyte Growth Factor Activator (HGFA) and Regulates HGFA Activity in the Pericellular Microenvironment

2000 • 126 citations

Distribution of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) in Human Tissues: Cellular Surface Localization of HAI-1 in Simple Columnar Epithelium and Its Modulated Expression in Injured and Regenerative Tissues

1999 • 115 citations

Characterization of Placental Bikunin, a Novel Human Serine Protease Inhibitor

1997 • 102 citations

Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells.

2001 • 99 citations

A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture

1992 • 97 citations

Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice.

1997 • 90 citations

Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor.

1996 • 86 citations

Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity

1992 • 85 citations

Identification and Cloning of Human Placental Bikunin, a Novel Serine Protease Inhibitor Containing Two Kunitz Domains

1997 • 82 citations

Identification of differentially expressed genes in hepatocellular carcinoma and metastatic liver tumors by oligonucleotide expression profiling

2001 • 78 citations

A Role for Membrane-Type Serine Protease (MT-SP1) in Intestinal Epithelial Turnover

2001 • 78 citations

Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP

1999 • 77 citations

Up-regulation of Vascular Endothelial Growth Factor Induced by Hepatocyte Growth Factor/Scatter Factor Stimulation in Human Glioma Cells

1998 • 76 citations

Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c‐met genes in human glioma cells in vitro

1995 • 73 citations

Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma.

1996 • 66 citations

Functional Characterization of Kunitz Domains in Hepatocyte Growth Factor Activator Inhibitor Type 1

2002 • 64 citations

Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model.

2002 • 63 citations

Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease

1992 • 61 citations

NK1, a Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is a Partial Agonist In Vivo

1998 • 58 citations

Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis

2000 • 58 citations

Activation of Hepatocyte Growth Factor (HGF) by Endogenous HGF Activator Is Required for Metanephric Kidney Morphogenesis in Vitro

2001 • 53 citations

Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer

1998 • 50 citations

Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: Implication for anti-invasive role of HAI-2/PB in glioblastoma cells

2001 • 49 citations

Multiple Sites of Proteolytic Cleavage to Release Soluble Forms of Hepatocyte Growth Factor Activator Inhibitor Type 1 from a Transmembrane Form

1999 • 47 citations

Hepatocyte Growth Factor Activator: A Possible Regulator of Morphogenesis during Fetal Development of the Rat Gastrointestinal Tract

1998 • 47 citations

Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation

1997 • 47 citations

Inductions of hepatocyte growth factor and its activator in rat brain with permanent middle cerebral artery occlusion

1998 • 41 citations

Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2

1998 • 38 citations

Emerging multifunctional aspects of cellular serine proteinase inhibitors in tumor progression and tissue regeneration

2002 • 38 citations

Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene

1998 • 35 citations

Analysis of tissue factor and tissue factor pathway inhibitor expression in human colorectal carcinoma cell lines and metastatic sublines to the liver

1997 • 35 citations

Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract

2000 • 33 citations

Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta

2000 • 33 citations

Hair Cycle-Dependent Expression of Hepatocyte Growth Factor (HGF) Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of HGF in Rat Hair Follicles

1999 • 33 citations

Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas

2000 • 31 citations

Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes

2000 • 29 citations

Hepatocyte Growth Factor Activator Inhibitor Type 2 Lacking the First Kunitz-Type Serine Proteinase Inhibitor Domain Is a Predominant Product in Mouse but Not in Human

1999 • 27 citations

Expression of Hepatocyte Growth Factor Activator and Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma

2001 • 27 citations

Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa

1998 • 27 citations

Production and Activation of Hepatocyte Growth Factor during the Healing of Rat Gastric Ulcers

1997 • 27 citations

Mouse Hepatocyte Growth Factor (HGF) Activator Inhibitor Type 2 Lacking the First Kunitz Domain Potently Inhibits the HGF Activator

2002 • 25 citations

CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells

2002 • 22 citations

Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy

1995 • 19 citations

Expression of Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) in Human Testis: Identification of a Distinct Transcription Start Site for the HAI-2 Gene in Testis

2002 • 18 citations

Pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF) in colorectal carcinomas: roles of HGF activator (HGFA) and HGFA inhibitor type 1 (HAI-1).

2001 • 17 citations

Cross-talk Between CD44 and c-Met in B cells

1999 • 14 citations

Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters

2001 • 13 citations