Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T cells.

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Tumor antigens recognized by T cells

1997 • 552 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells

1998 • 303 citations

MHC antigens and tumor escape from immune surveillance

2001 • 300 citations

Galectin-1 Is a Major Receptor for Ganglioside GM1, a Product of the Growth-controlling Activity of a Cell Surface Ganglioside Sialidase, on Human Neuroblastoma Cells in Culture

1998 • 284 citations

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

2001 • 222 citations

Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes.

1999 • 218 citations

Shedding from the Cell Surface of Normal and Cancer Cells

1980 • 215 citations

Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

2000 • 206 citations

Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

2000 • 199 citations

Shedding and immunoregulatory activity of YAC-1 lymphoma cell gangliosides.

1983 • 191 citations

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

2001 • 189 citations

Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.

2002 • 186 citations

Bcl-2 and Mitochondrial Oxygen Radicals

1999 • 178 citations

A solvent partition method for microscale ganglioside purification

1985 • 175 citations

Tumor Gangliosides Inhibit the Tumor-Specific Immune Response

1999 • 164 citations

T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.

1993 • 158 citations

Where have all the T cells gone? Mechanisms of immune evasion by tumors

1999 • 153 citations

Establishment and characterization of human renal cancer and normal kidney cell lines.

1990 • 152 citations

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma.

1999 • 145 citations

Gangliosides shed by tumor cells enhance tumor formation in mice.

1987 • 144 citations

Shed tumor gangliosides and progression of human neuroblastoma

1990 • 132 citations

Glycolipid-bound sialic acid in serum: increased levels in mice and humans bearing mammary carcinomas.

1977 • 132 citations

Apoptogenic Ganglioside GD3 Directly Induces the Mitochondrial Permeability Transition

1999 • 131 citations

Lack of interleukin‐2 (IL‐2) expression and selective expression of IL‐10 mRNA in human renal cell carcinoma

1995 • 129 citations

Evidence for the existence of ganglioside-enriched plasma membrane domains in human peripheral lymphocytes

1997 • 127 citations

Renal cell carcinoma–derived gangliosides suppress nuclear factor-κB activation in T cells

1999 • 124 citations

Immunosuppression by human gangliosides: I. Relationship of carbohydrate structure to the inhibition of T cell responses

1992 • 119 citations

The role of Fas/FasL in immunosuppression induced by human tumors

1998 • 115 citations

Immunosuppression by human gangliosides

1992 • 105 citations

Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.

1999 • 105 citations

Modulation of the immune response by gangliosides. Inhibition of adherent monocyte accessory function in vitro.

1984 • 102 citations

Influence of Cellular Ganglioside Depletion on Tumor Formation

2000 • 96 citations

Selective cytokine gene expression in renal cell carcinoma tumor cells and tumor‐infiltrating lymphocytes

1995 • 93 citations

Possible role for glycosphingolipids in the control of immune responses

1979 • 93 citations

Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events

2000 • 92 citations

Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2

1999 • 90 citations

Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma.

1999 • 82 citations

Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

2001 • 82 citations

Ganglioside antigens expressed by human cancer cells.

1991 • 77 citations

Characterization of Tumor-Infiltrating Lymphocyte Subsets from Human Renal Cell Carcinoma: Specific Reactivity Defined by Cytotoxicity, Interferon-?? Secretion, and Proliferation

1994 • 75 citations

Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor

2002 • 71 citations

Human tumor gangliosides inhibit murine immune responses in vivo.

1995 • 70 citations

GD3 Recruits Reactive Oxygen Species to Induce Cell Proliferation and Apoptosis in Human Aortic Smooth Muscle Cells

2002 • 68 citations

Disialosyl galactosylgloboside as an adhesion molecule expressed on renal cell carcinoma and its relationship to metastatic potential.

1996 • 65 citations

Gangliosides block antigen presentation by human monocytes

1996 • 65 citations

A Novel Ganglioside Isolated from Renal Cell Carcinoma

2001 • 62 citations

The role of glycosphingolipids in natural immunity. gangliosides modulate the cytotoxicity of natural killer cells

1989 • 62 citations

Impaired Activation of NFκB in T Cells From a Subset of Renal Cell Carcinoma Patients Is Mediated by Inhibition of Phosphorylation and Degradation of the Inhibitor, IκB

1998 • 59 citations

Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution

2002 • 57 citations

True

2000 • 54 citations

Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression.

2001 • 45 citations

Melanoma vaccines: the paradox of T cell activation without clinical response

2000 • 45 citations

Tumor-induced apoptosis of T cells: amplification by a mitochondrial cascade.

2000 • 41 citations

Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line

2002 • 40 citations

Involvement of gangliosides and glycoprotein fibronectin receptors in cellular adhesion to fibronectin

1988 • 38 citations

A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity

2002 • 38 citations

Bcl-2 Inhibits Apoptosis Induced by Mitochondrial Uncoupling but Does Not Prevent Mitochondrial Transmembrane Depolarization

2001 • 36 citations

T cell-mediated immune responses in melanoma: implications for immunotherapy

2002 • 30 citations

Renal cell carcinoma : molecular biology, immunology, and clinical management

2000 • 27 citations

Antigen-Driven T-Cell Selection in Patients with Cervical Cancer as Evidenced by T-Cell Receptor Analysis and Recognition of Autologous Tumor

2002 • 19 citations

The T cell death knell: immune-mediated tumor death in renal cell carcinoma.

2001 • 18 citations

Molecular Mechanisms of Immune Dysfunction in Renal Cell Carcinoma

2000 • 18 citations

Cytokine-based therapy for melanoma: pre-clinical studies.

2000 • 12 citations

Specific immunotherapy against occult cancer metastases

2002 • 6 citations