The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new method for sequencing DNA.

1977 • 7,941 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

The Metabolic Basis of Inherited Disease

1979 • 2,083 citations

Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders

1967 • 1,945 citations

SUPERCOILED CIRCULAR DNA-PROTEIN COMPLEX IN Escherichia coli : PURIFICATION AND INDUCED CONVERSION TO AN OPEN CIRCULAR DNA FORM

1969 • 1,847 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

1977 • 654 citations

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

1981 • 568 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

THE MUTATION AND POLYMORPHISM OF THE HUMAN β-GLOBIN GENE AND ITS SURROUNDING DNA

1984 • 404 citations

Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.

1981 • 391 citations

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

1985 • 352 citations

Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.

1982 • 349 citations

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

1981 • 316 citations

Familial apolipoprotein E deficiency.

1986 • 300 citations

Nucleotide sequence and structure of the human apolipoprotein E gene.

1985 • 289 citations

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

1978 • 277 citations

Type III Hyperlipoproteinemia Associated with Apolipoprotein E Deficiency

1981 • 272 citations

PSEUDOMEMBRANOUS COLITIS ASSOCIATED WITH CLINDAMYCIN

1974 • 270 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

Rate and equilibrium constants for binding of apo-E HDL _c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL _c

1979 • 215 citations

Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages

1985 • 200 citations

beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

1984 • 197 citations

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

1984 • 188 citations

Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency.

1980 • 188 citations

Type III Hyperlipoproteinemia: Defective Metabolism of an Abnormal Apolipoprotein E

1981 • 183 citations

Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.

1984 • 178 citations

Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2

1982 • 177 citations

Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus.

1983 • 168 citations

Hepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.

1982 • 164 citations

Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates.

1985 • 147 citations

Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.

1983 • 146 citations

Abnormal lipid composition of very low density lipoproteins in diagnosis of broad-beta disease (Type III hyperlipoproteinemia)

1972 • 136 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

DNA sequence of the early E3 transcription unit of adenovirus 5

1985 • 116 citations

Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells.

1982 • 107 citations

TYPE-III HYPERLIPOPROTEINÆMIA ("REMNANT REMOVAL DISEASE")

1977 • 85 citations

Parent-offspring and sibling lipid and lipoprotein associations during and after sharing of household environments: The Princeton School District Family Study

1982 • 67 citations

[49] Genetic polymorphism in human apolipoprotein E

1986 • 59 citations

Broad-β Disease (Type III Hyperlipoproteinemia) in a Large Kindred

1975 • 49 citations

mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency.

1985 • 21 citations

Expression of Cloned Growth Hormone and Metallothionein Genes in Heterologous Cells

1983 • 16 citations

[40] Intra- and extracellular modifications of apolipoproteins

1986 • 14 citations