Pathophysiology of hepatic encephalopathy: a new look at ammonia.

Biochemistry and physiology of brain ammonia.

1987 • 829 citations

Cerebral herniation in patients with acute E liver failure is correlated with arterial ammonia concentration

1999 • 658 citations

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts.

1977 • 430 citations

The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia.

1979 • 406 citations

Ammonia: Key factor in the pathogenesis of hepatic encephalopathy

1987 • 397 citations

Cerebral Ammonia Metabolism in Patients with Severe Liver Disease and Minimal Hepatic Encephalopathy

1991 • 328 citations

Therapeutic efficacy ofL-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: Results of a placebo-controlled, double-blind study

1997 • 314 citations

Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats

1992 • 264 citations

Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma.

1974 • 263 citations

Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure

1992 • 222 citations

Proton magnetic resonance spectroscopy of the brain in symptomatic and asymptomatic patients with liver cirrhosis

1997 • 216 citations

Amino Acid Changes in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy

1987 • 189 citations

Morphologic Effects of Ammonia on Primary Astrocyte Cultures. I. Light Microscopic Studies

1985 • 158 citations

Reversible Toxic Manifestations in Patients with Cirrhosis of the Liver Given Cation-Exchange Resins

1952 • 152 citations

Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: Ultrastructure and integrity of the blood-brain barrier

1987 • 149 citations

Elevated protein requirements in cirrhosis of the liver investigated by whole body protein turnover studies

1988 • 114 citations

L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

1998 • 86 citations

Ammonia Production in the Human Colon

1970 • 85 citations

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy

1984 • 85 citations

Loss of expression of glial fibrillary acidic protein in acute hyperammonemia

2002 • 82 citations

Cerebral Cortex Ammonia and Glutamine Metabolism During Liver Insufficiency‐Induced Hyperammonemia in the Rat

1992 • 62 citations

Neurological features and computed tomography of the brain in children with ornithine carbamoyl transferase deficiency.

1983 • 61 citations

BRAIN HISTOLOGY AND BEHAVIOR OF MICE INJECTED WITH UREASE

1974 • 57 citations

Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy.

1999 • 54 citations

Cerebral aminoacids in portal-systemic encephalopathy: Lack of evidence for altered ?-aminobutyric acid (GABA) function

1986 • 40 citations

Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy.

1998 • 27 citations

Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues

1999 • 22 citations

Hepatic encephalopathy studies with astrocyte cultures

1988 • 15 citations