Biotechnology: identifying advances from the hype

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Construction of Biologically Functional Bacterial Plasmids In Vitro

1973 • 1,699 citations

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.

1978 • 841 citations

Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment of Patients With Advanced Cancer

1993 • 639 citations

Conventional-Dose Chemotherapy Compared with High-Dose Chemotherapy plus Autologous Hematopoietic Stem-Cell Transplantation for Metastatic Breast Cancer

2000 • 474 citations

Will Genetics Revolutionize Medicine?

2000 • 411 citations

Knockouts model the 100 best-selling drugs—will they model the next 100?

2002 • 392 citations

Current Developments in Cancer Vaccines and Cellular Immunotherapy

2003 • 300 citations

Investing in nanotechnology

2003 • 171 citations

Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloro-ethylamine and nitrogen mustard residues.

1967 • 160 citations

Complex Disease and the New Clinical Sciences

2002 • 141 citations

The Phase III Trial in the Era of Targeted Therapy: Unraveling the “Go or No Go” Decision

2003 • 108 citations

Evaluating the Health Risks of Breast Implants: The Interplay of Medical Science, the Law, and Public Opinion

1996 • 106 citations

Antisense Has Growing Pains

1995 • 99 citations

Cell-based therapies go live

2002 • 90 citations

New drug approvals for 2002

2003 • 51 citations

Dr. Folkman's war: angiogenesis and the struggle to defeat cancer

2001 • 35 citations

Dr. Folkman's War: Angiogenesis and the Struggle to Defeat Cancer

2001 • 23 citations

Moving beyond the genome projects

1996 • 15 citations

Studies reveal potential pitfalls of RNAi

2003 • 12 citations

Biotech's billion dollar breakthrough.

2003 • 8 citations

Gene therapy for the hemoglobin disorders.

2003 • 8 citations

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