Regulators of Small GTPases

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Small GTP-Binding Proteins

1992 • 526 citations

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1990 • 465 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product

1992 • 296 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein

1992 • 175 citations

Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.

1992 • 159 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.

1990 • 154 citations

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

1992 • 147 citations

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

1989 • 137 citations

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

1990 • 125 citations

Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.

1993 • 123 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

1992 • 107 citations

MAP kinase regulation — the oncogene connection

1992 • 76 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

A novel epidermal cell differentiation inhibitor (EDIN): Purification and characterization from Staphylococcusaureus

1990 • 73 citations

Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein.

1992 • 72 citations

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.

1992 • 63 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations

The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.

1992 • 37 citations

Cooperative function of rho GDS and rho GDI to regulate rho p21 activation in smooth muscle

1992 • 19 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 17 citations