Thermogenesis in Brown Adipose Tissue as an Energy Buffer

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

A role for brown adipose tissue in diet-induced thermogenesis

1979 • 1,587 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline

1978 • 653 citations

Endocrine and Metabolic Effects of Experimental Obesity in Man

1973 • 554 citations

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

1979 • 509 citations

Neural Organization and Evolution of Thermal Regulation in Mammals

1978 • 508 citations

Effect of Diet and Cold Exposure on Norepinephrine Turnover in Brown Adipose Tissue of the Rat

1982 • 348 citations

The occurrence of brown adipose tissue in outdoor workers

1981 • 325 citations

Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus

1981 • 321 citations

Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals

1980 • 302 citations

Reduced thermogenesis in obesity

1979 • 296 citations

Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse

1978 • 257 citations

Smoking and its effects on body weight and the systems of caloric regulation

1982 • 255 citations

The Brown Fat Cell

1982 • 233 citations

Luxuskonsumption, Diet-Induced Thermogenesis and Brown Fat: The Case in Favour

1983 • 225 citations

A mitochondrial defect in brown adipose tissue of the obese (obob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding

1978 • 212 citations

Regional blood flow in genetically obese (ob/ob) mice

1980 • 180 citations

Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats

1978 • 179 citations

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

1982 • 168 citations

Influence of noradrenaline on blood flow to brown adipose tissue in rats exhibiting diet-induced thermogenesis

1981 • 166 citations

Postprandial Thermogenesis in Obesity

1981 • 161 citations

Exclusive occurrence of thermogenin antigen in brown adipose tissue

1982 • 161 citations

Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis

1980 • 160 citations

REGULATION OF ENERGY BALANCE

1981 • 155 citations

Similarities between cold- and diet-induced thermogenesis in the rat

1980 • 152 citations

Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice

1982 • 149 citations

EFFECT OF THE THERMAL ENVIRONMENT ON COLD RESISTANCE AND GROWTH OF SMALL INFANTS AFTER THE FIRST WEEK OF LIFE

1968 • 137 citations

The Thermogenic Response of the Newborn Infant to Noradrenaline¹

1962 • 137 citations

The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings

1979 • 136 citations

Experimental obesity, dietary-induced thermogenesis, and their clinical implications

1976 • 135 citations

Impaired Suppression of Sympathetic Activity during Fasting in the Gold Thioglucose-treated Mouse

1980 • 128 citations

A Virally Induced Obesity Syndrome in Mice

1982 • 127 citations

Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis

1981 • 126 citations

Obesity may be due to a malfunctioning of brown fat.

1979 • 123 citations

Metabolic effects of altering the 24 h energy intake in man, using direct and indirect calorimetry

1980 • 121 citations

Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice

1982 • 120 citations

Metabolic relationships between lipolysis and respiration in rat brown adipocytes. The role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis.

1981 • 118 citations

Thermoregulation in the diabetic-obese (db/db) mouse

1979 • 104 citations

Caffeine: Its Effect on Catecholamines and Metabolism in Lean and Obese Humans

1981 • 99 citations

Effect of chronic food restriction on energy balance, thermogenic capacity, and brown-adipose-tissue activity in the rat

1982 • 98 citations

Role of thyroid hormone in cold-induced changes in rat brown adipose tissue mitochondria

1982 • 95 citations

Effects of Feeding a “Cafeteria” Diet on Energy Balance and Diet-Induced Thermogenesis in Four Strains of Rat

1982 • 94 citations

RESISTANCE TO SLIMMING ADAPTATION OR ILLUSION ?

1975 • 92 citations

AN INTEGRATED VIEW OF THE METABOLIC AND GENETIC BASIS FOR OBESITY

1976 • 91 citations

An Assessment of Human Regulatory Nonshivering Thermogenesis

1980 • 91 citations

Measurement of rat brown-adipose-tissue mitochondrial uncoupling protein by radioimmunoassay: Increased concentration after cold acclimation

1983 • 86 citations

Spontaneous sweat secretion in calcium-free strontium medium

1982 • 84 citations

Maintenance Requirement and Energetic Efficiency of Lean and Obese Zucker Rats

1976 • 82 citations

THERMAL NEUTRALITY

1975 • 81 citations

GDP binding to brown-adipose-tissue mitochondria of diabetic-obese (db/db) mice. Decreased binding in both the obese and pre-obese states

1981 • 80 citations

An immunological study of the uncoupling protein of brown adipose tissue mitochondria

1983 • 79 citations

Uncoupling protein in human brown adipose tissue mitochondria

1983 • 77 citations

Brown Adipose Tissue Thermogenesis in Obese Animals

2009 • 74 citations

Comparison of microspheres and ⁸⁶Rb⁺ as tracers of the distribution of cardiac output in rats indicates invalidity of ⁸⁶Rb⁺-based measurements

1978 • 69 citations

Acute effects of food, 2-deoxy-d-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats

1981 • 67 citations

Nutritional Effects on Thyroid and Catecholamine Metabolism

1980 • 62 citations

Increased thermal body insulation: relationship to the development of obesity.

1974 • 62 citations

Studies on the activity of brown adipose tissue in suckling, pre-obese, obob mice

1982 • 60 citations

EFFECTS OF DIET AND ACUTE NORADRENALINE TREATMENT ON BROWN ADIPOSE TISSUE DEVELOPMENT AND MITOCHONDRIAL PURINE‐NUCLEOTIDE BINDING

1982 • 57 citations

Thyroid Hormones and Thermogenesis

1983 • 55 citations

Effect of diet and exercise on norepinephrine-induced thermogenesis in male and female rats

1982 • 54 citations

Thermogenic response to insulin and glucose infusions in man: A model to evaluate the different components of the thermic effect of carbohydrate

1982 • 49 citations

The Production of Heat by Fat

1965 • 48 citations

Alterations of Brown Adipose Tissue in Genetically Obese (ob/ob) Mice. I. Demonstration of Loss of Metabolic Response to Nerve Stimulation and Catecholamines and Its Partial Recovery after Fasting or Cold Adaptation*

1982 • 46 citations

Factors influencing the acute effect of food on oxygen consumption in the rat.

1982 • 45 citations

The development of obesity in genetically diabetic-obese (db/db) mice pair-fed with lean siblings

1980 • 38 citations

Effects of Early Overnutrition and Undernutrition in Rats on the Metabolic Responses to Overnutrition in Later Life

1982 • 37 citations

Decreased guanine nuleotide binding and reduced equivalent production by brown adipose tissue in hypothalamic obesity

1982 • 34 citations

Plasma catecholamines and autonomic responsiveness in obesity.

1982 • 32 citations

Catecholamine and Thyroid Hormone Influence on Brown Fat Na⁺, K⁺-ATPase Activity and Thermogenesis in the Rat

1982 • 30 citations

Cellular Mechanisms of Heat Dissipation

1983 • 30 citations

A THERMOGRAPHIC STUDY OF INFANTS EXPOSED TO COLD

1972 • 28 citations

Hypothalamic regulation of lipid metabolism in the rat: effect of hypothalamic stimulation on lipogenesis

1982 • 27 citations

Growth of interscapular brown adipose tissue in cold-acclimated hypophysectomized rats maintained on thyroxine and corticosterone

1982 • 27 citations

Does a thermogenic defect play a role in the pathogenesis of human obesity?

1983 • 27 citations

Enhancement of calorigenic response to cold and to norepinephrine in physically trained rats.

1981 • 25 citations

Effects of exercise in cool water on body weight loss.

1982 • 24 citations

Nonshivering thermogenesis in the newborn

1980 • 23 citations

Adenylate cyclase activity in brown adipose tissue of the genetically obese (ob/ob) mouse

1982 • 14 citations

Changes in Metabolic Rate and Brown Adipose Tissue Composition during Nutritional Rehabilitation of Postnatally Undernourished Rats

1982 • 9 citations