TGF-β2 Reduces Demyelination, Virus Antigen Expression, and Macrophage Recruitment in a Viral Model of Multiple Sclerosis

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

Primary demyelination in Theiler's virus infection. An ultrastructural study.

1975 • 273 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1976 • 242 citations

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

1995 • 179 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Role of macrophages during Theiler's virus infection

1997 • 130 citations

Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody.

1988 • 128 citations

CD4⁺and CD8⁺T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis

1998 • 117 citations

Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.

1994 • 116 citations

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

1986 • 104 citations

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system

1993 • 103 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function

1989 • 84 citations

Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease.

1995 • 76 citations

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination

1995 • 76 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice

1996 • 68 citations

Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue

1997 • 61 citations

Theiler's virus infection induces a specific cytotoxic T lymphocyte response

1991 • 57 citations

Transforming growth factor-β1 induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression

1997 • 55 citations

Inhibition of Theiler's Virus-induced demylination in vivo by tumor necrosis factor alpha

1990 • 53 citations

Theiler's virus replication in brain macrophages cultured in vitro

1992 • 52 citations

Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination

1986 • 50 citations

Characterization of B lymphocytes present in the demyelinating lesions induced by Theiler's virus.

1989 • 43 citations

Transforming growth factor-β inhibits apoptosis induced by β-amyloid peptide fragment 25–35 in cultured neuronal cells

1998 • 43 citations

Erichrome Stain for Myelin on Osmicated Tissue Embedded in Glycol Methacrylate Plastic

1989 • 42 citations

Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation

1990 • 42 citations

Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene

1990 • 39 citations

VP1 and VP2 Capsid Proteins of Theiler's Virus Are Targets of H-2D-Restricted Cytotoxic Lymphocytes in the Central Nervous System of B10 Mice

1995 • 38 citations

Differential generation of class I H‐2D‐ versus H‐2K‐restricted cytotoxicity against a demyelinating virus following central nervous system infection

1997 • 36 citations

Theiler’s Virus Infection of Genetically Susceptible Mice Induces Central Nervous System-Infiltrating CTLs with no Apparent Viral or Major Myelin Antigenic Specificity

1998 • 35 citations

In vivo administration of interleukin-2 protects susceptible mice from Theiler's virus persistence

1997 • 22 citations

Expression of human HLA-B27 transgene alters susceptibility to murine Theiler's virus-induced demyelination.

1991 • 19 citations

Expression of the human histocompatibility leukocyte antigen DR3 transgene reduces the severity of demyelination in a murine model of multiple sclerosis.

1998 • 16 citations

Human class I major histocompatibility complex transgene prevents virus‐induced demyelination in susceptible mutant B 10.d2^dml mice

1993 • 13 citations

Failure of treatment with Linomide or oral myelin tolerization to ameliorate demyelination in a viral model of multiple sclerosis

1998 • 13 citations

Transforming growth factor-beta 1 enhances the generation of allospecific cytotoxic T lymphocytes.

1993 • 13 citations

Antigenic variants are not selected during persistent infection with Theiler's virus

1983 • 7 citations

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