Protein families and RNA recognition

The PyMOL Molecular Graphics System

2002 • 18,218 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Structure of the 30S ribosomal subunit

2000 • 2,000 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae

2004 • 960 citations

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

1998 • 935 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

1994 • 827 citations

Homeodomain-DNA recognition

1994 • 784 citations

The kink-turn: a new RNA secondary structure motif

2001 • 729 citations

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

2004 • 717 citations

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

1991 • 635 citations

Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 Ψ-RNA Recognition Element

1998 • 631 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex

1996 • 587 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Recognition of Polyadenylate RNA by the Poly(A)-Binding Protein

1999 • 494 citations

Modular Recognition of RNA by a Human Pumilio-Homology Domain

2002 • 490 citations

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 • 472 citations

Structure and conserved RNA binding of the PAZ domain

2003 • 468 citations

Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs

1999 • 467 citations

Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA

1990 • 446 citations

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

2003 • 442 citations

Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner

1994 • 435 citations

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein

2002 • 431 citations

The Solution Structure of the S1 RNA Binding Domain: A Member of an Ancient Nucleic Acid–Binding Fold

1997 • 407 citations

RNase III enzymes and the initiation of gene silencing

2004 • 387 citations

RNA recognition by a Staufen double-stranded RNA-binding domain

2000 • 360 citations

Solution Structure of a Bovine Immunodeficiency Virus Tat-TAR Peptide-RNA Complex

1995 • 343 citations

Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

2004 • 342 citations

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d

2004 • 339 citations

A Detailed View of a Ribosomal Active Site

1999 • 332 citations

Sequence-Specific RNA Binding by a Nova KH Domain

2000 • 323 citations

RNA RECOGNITION BY RNP PROTEINS DURING RNA PROCESSING

1998 • 299 citations

High Affinity Binding of TAR RNA by the Human Immunodeficiency Virus Type-1 tat Protein Requires Base-pairs in the RNA Stem and Amino Acid Residues Flanking the Basic Region

1993 • 281 citations

Crystal Structure of the Spliceosomal 15.5kD Protein Bound to a U4 snRNA Fragment

2000 • 277 citations

RNA recognition by an isolated α helix

1993 • 265 citations

NMR Structure of the Bacteriophage λ N Peptide/boxB RNA Complex: Recognition of a GNRA Fold by an Arginine-Rich Motif

1998 • 264 citations

NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.

1995 • 262 citations

Cocrystal Structure of a tRNA Ψ55 Pseudouridine Synthase

2001 • 262 citations

Crystal Structure of the MATa1/MATα2 Homeodomain Heterodimer Bound to DNA

1995 • 260 citations

Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA

1999 • 258 citations

Crystal Structure of a Conserved Ribosomal Protein-RNA Complex

1999 • 258 citations

RNA recognition: A family matter?

1993 • 253 citations

Miranda mediates asymmetric protein and RNA localization in the developing nervous system

1998 • 246 citations

Structure of Pumilio Reveals Similarity between RNA and Peptide Binding Motifs

2001 • 245 citations

Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation

1996 • 245 citations

Crystal Structure of a Pumilio Homology Domain

2001 • 244 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

U2AF homology motifs: protein recognition in the RRM world

2004 • 239 citations

Proteins binding to duplexed RNA: one motif, multiple functions

2000 • 239 citations

Crystallographic and Modeling Studies of RNase III Suggest a Mechanism for Double-Stranded RNA Cleavage

2001 • 230 citations

Structural basis for recognition of AU-rich element RNA by the HuD protein.

2001 • 226 citations

Minor-Groove Recognition of Double-Stranded RNA by the Double-Stranded RNA-Binding Domain from the RNA-Activated Protein Kinase PKR

1996 • 222 citations

Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF65 and SF1/mBBP

2003 • 212 citations

Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin

2000 • 207 citations

The structure of trp RNA-binding attenuation protein

1995 • 202 citations

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

1991 • 200 citations

Crystal structure of a zinc-finger–RNA complex reveals two modes of molecular recognition

2003 • 196 citations

Eleven down and nine to go

1995 • 194 citations

Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat.

1988 • 193 citations

Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex

1995 • 177 citations

Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III

2004 • 153 citations

The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA

1992 • 152 citations

Crystal structure of the ribosomal protein S6 from Thermus thermophilus.

1994 • 147 citations

Crystal structure of the ribosomal protein S6 from Thermus thermophilus.

1994 • 137 citations

Model of the Brain Tumor–Pumilio translation repressor complex

2003 • 116 citations

Crystal Structures of the Pyrococcus abyssi Sm Core and Its Complex with RNA

2003 • 110 citations

Hydrogen-bonding Contacts in the Major Groove are required for Human Immunodeficiency Virus Type-1 tat Protein Recognition of TAR RNA

1993 • 109 citations

A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme?

1994 • 105 citations

Structural Basis for Telomeric Single-stranded DNA Recognition by Yeast Cdc13

2004 • 100 citations

Binding of the Protein Kinase PKR to RNAs with Secondary Structure Defects: Role of the Tandem A−G Mismatch and Noncontiguous Helixes

1998 • 97 citations

Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1.

1989 • 96 citations

Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics: Ligands with High Affinity and Selectivity for Viral TAR RNA Regulatory Elements

2004 • 93 citations

Dissecting RNA-protein interactions: RNA-RNA recognition by Rop

1995 • 92 citations

Induced Folding in RNA–Protein Recognition: More than a Simple Molecular Handshake

1998 • 90 citations

Independent Ligand-Induced Folding of the RNA-Binding Domain and Two Functionally Distinct Antitermination Regions in the Phage λ N Protein

1998 • 86 citations

A new α-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III

2004 • 59 citations

Ribosomal protein S17: Characterization of the three-dimensional structure by proton and nitrogen-15 NMR

1993 • 58 citations

Ribosomal proteins and elongation factors

1995 • 54 citations

Structure of the Equine Infectious Anemia Virus Tat Protein

1994 • 52 citations

Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda.

1995 • 50 citations

Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev

1990 • 47 citations

TFIIIA: nine fingers - three hands?

1993 • 45 citations

Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation.

1991 • 37 citations

A Physical Interaction between Gar1p and Rnt1p Is Required for the Nuclear Import of H/ACA Small Nucleolar RNA-Associated Proteins

2002 • 25 citations