Secretion of somatostatin by Saccharomyces cerevisiae. Correct proteolytic processing of pro-alpha-factor-somatostatin hybrids requires the products of the KEX2 and STE13 genes.

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Transformation of yeast.

1978 • 2,267 citations

Staphylococcal Protease: A Proteolytic Enzyme Specific for Glutamoyl Bonds

1972 • 703 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor

1982 • 587 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

1984 • 477 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

1983 • 403 citations

Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish

1980 • 337 citations

Heterologous Protein Secretion from Yeast

1985 • 299 citations

Protein Localization and Membrane Traffic in Yeast

1985 • 267 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and α-factor precursor processing

1987 • 183 citations

Protein secretion from Saccharomyces cerevisiae directed by the prepro-alpha-factor leader region.

1986 • 144 citations

Secretion of foreign proteins from Saccharomyces cerevisiae directed by alpha-factor gene fusions.

1984 • 126 citations

Expression of preprosomatostatin in heterologous cells: Biosynthesis, posttranslational processing, and secretion of mature somatostatin

1984 • 96 citations

Protein Transport and Secretion

1986 • 92 citations

A novel protease from yeast with specificity towards paired basic residues

1984 • 82 citations

Secretion of mature mouse interleukin-2 by Saccharomyces cerevisiae: use of a general secretion vector containing promoter and leader sequences of the mating pheromone α-factor

1985 • 74 citations

Saccharomyces cerevisiae Secretes and Correctly Processes Human Interferon Hybrid Proteins Containing Yeast Invertase Signal Peptides

1986 • 55 citations

In vitro biosynthesis of fish islet preprosomatostatin: evidence of processing and segregation of a high molecular weight precursor.

1980 • 55 citations

Expression and secretion of biologically active human atrial natriuretic peptide in Saccharomyces cerevisiae.

1986 • 53 citations

Somatostatin: Basic And Clinical Status

2013 • 51 citations

Secretion of somatostatin by Saccharomyces cerevisiae. Correct processing of an alpha-factor-somatostatin hybrid.

1986 • 39 citations

Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins.

1984 • 37 citations

Cotranslational and posttranslational proteolytic processing of preprosomatostatin-I in intact islet tissue.

1986 • 29 citations

[59] Yeast vectors for production of interferon

1986 • 13 citations