Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

1990 • 2,630 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Dopamine: A Prolactin-Inhibiting Hormone*

1985 • 735 citations

Alternative splicing directs the expression of two D2 dopamine receptor isoforms

1989 • 692 citations

Molecular cloning and expression of the gene for a human D1 dopamine receptor

1990 • 675 citations

Multiple D2 dopamine receptors produced by alternative RNA splicing

1989 • 642 citations

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.

1990 • 636 citations

The dopamine D2 receptor: two molecular forms generated by alternative splicing.

1989 • 596 citations

Cloning and expression of human and rat Dt dopamine receptors

1990 • 566 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Cloning of the cDNA and gene for a human D2 dopamine receptor.

1989 • 488 citations

Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

1990 • 471 citations

A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.

1989 • 352 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Transcriptional regulation of the prolactin gene by ergocryptine and cyclic AMP

1981 • 276 citations

Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells.

1984 • 258 citations

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain

1988 • 238 citations

Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells.

1990 • 235 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues

1990 • 215 citations

A Protein Kinase Inhibitor Gene Reduces Both Basal and Multihormone-stimulated Prolactin Gene Transcription

1989 • 203 citations

Both Pit-1 and the Estrogen Receptor Are Required for Estrogen Responsiveness of the Rat Prolactin Gene

1990 • 200 citations

Both Isoforms of the cAMP-dependent Protein Kinase Catalytic Subunit Can Activate Transcription of the Prolactin Gene

1989 • 162 citations

Two Different cis -Active Elements Transfer the Transcriptional Effects of Both EGF and Phorbol Esters

1986 • 161 citations

Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.

1990 • 149 citations

Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells.

1985 • 147 citations

Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP

1982 • 143 citations

A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus

1990 • 143 citations

The Homeodomain Protein, Pit-1/GHF-1, Is Capable of Binding to and Activating Cell-Specific Elements of Both the Growth Hormone and Prolactin Gene Promoters

1990 • 127 citations

Calcium specifically stimulates prolactin synthesis and messenger RNA sequences in GH3 cells.

1981 • 117 citations

A Family of POU-Domain and Pit-1 Tissue-Specific Transcription Factors in Pituitary and Neuroendocrine Development

1990 • 115 citations

The Distal Enhancer Region of the Rat Prolactin Gene Contains Elements Conferring Response to Multiple Hormones

1989 • 111 citations

Inhibition of inositol phosphate production is a late, Ca2+-dependent effect of D2 dopaminergic receptor activation in rat lactotroph cells.

1988 • 103 citations

Clustered Point Mutation Analysis of the Rat Prolactin Promoter

1990 • 101 citations

A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.

1990 • 78 citations

Pituitary Calcium Channel Modulation and Regulation of Prolactin Gene Expression

1990 • 64 citations

Proximal Upstream Flanking Sequences Direct Calcium Regulation of the Rat Prolactin Gene

1988 • 61 citations

Transcriptional Regulation of the Human Transforming Growth Factor-α Gene

1991 • 57 citations

Transforming Growth Factor-α Expression in the Anterior Pituitary Gland: Regulation by Epidermal Growth Factor and Phorbol Ester in Dispersed Cells

1989 • 56 citations

Preferential Role of Calcium in the Regulation of Prolactin Gene Transcription by Thyrotropin-Releasing Hormone in GH₃Pituitary Cells*

1988 • 54 citations

Blockade of low and high threshold Ca2+ channels by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expression.

1990 • 49 citations

Dual mechanisms of inhibition by dopamine of basal and thyrotropin-releasing hormone-stimulated inositol phosphate production in anterior pituitary cells. Evidence for an inhibition not mediated by voltage-dependent Ca2+ channels.

1990 • 46 citations

Analysis of Rat Prolactin Promoter Sequences that Mediate Pituitary-Specific and 3′,5′-Cyclic Adenosine Monophosphate-Regulated Gene Expressionin Vivo

1989 • 45 citations

Dopamine regulates expression of the glandular-type kallikrein gene at the transcriptional level in the pituitary.

1987 • 45 citations

Calcium Induction of the mRNAs for Prolactin and c-fos Is Independent of Protein Kinase C Activity

1989 • 41 citations

The Hormonal Regulation of Prolactin Gene Expression: An Examination of Mechanisms Controlling Prolactin Synthesis and the Possible Relationship of Estrogen to These Mechanisms

1986 • 41 citations

Calcium/Calmodulin Regulation of the Rat Prolactin Gene is Conferred by the Proximal Enhancer Region

1991 • 20 citations

DNA recognition element required for PUF-I mediated cell-type-specific transcription of the rat prolactin gene

1989 • 17 citations

Tissue-specific regulation of prolactin gene expression

1990 • 12 citations

Response and Binding Elements for Ligand-dependent Positive Transcription Factors Integrate Positive and Negative Regulation of Gene Expression

1988 • 9 citations

Disappearance in high-K+ medium of receptor-mediated inhibition of adenylate cyclase in guinea-pig cortical slices

1990 • 2 citations