Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.

1975 • 619 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

1992 • 343 citations

RECOMBINANT TOXINS AS NOVEL THERAPEUTIC AGENTS

1992 • 325 citations

Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

1984 • 286 citations

Receptor for Interleukin 13

1995 • 266 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: A phase II trial

1992 • 147 citations

Human neurological cancer cells express interleukin‐4 (IL‐4) receptors which are targets for the toxic effects of IL4‐pseudomonas exotoxin chimeric protein

1994 • 117 citations

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

1993 • 109 citations

Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

1988 • 108 citations

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme.

1994 • 104 citations

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line.

1990 • 92 citations

Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro.

1994 • 83 citations

Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

1994 • 76 citations

A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin

1993 • 69 citations

The epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies.

1990 • 64 citations

Immunotherapy of human glioma xenografts with unlabeled, 131I-, or 125I-labeled monoclonal antibody 425 to epidermal growth factor receptor.

1992 • 61 citations

Epidermal growth factor receptors on ependymomas and other brain tumors

1990 • 47 citations

Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells

1993 • 46 citations

Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice.

1992 • 41 citations

Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.

1991 • 36 citations

An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin

1994 • 35 citations

Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimericPseudomonas exotoxin

1994 • 21 citations

Oncogene-related growth factors and growth factor receptors in human malignant glioma-derived cell lines

1989 • 20 citations