Serotonin-Immune Interactions in Major Depression

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.

1998 • 1,130 citations

The macrophage theory of depression

1991 • 871 citations

Psychopharmacology: The Fourth Generation of Progress

1996 • 755 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Depression, stress and immunological activation: The role of cytokines in depressive disorders

1998 • 479 citations

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

1993 • 440 citations

Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs

1997 • 344 citations

Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells

1996 • 311 citations

Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine

1995 • 301 citations

Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1.

1992 • 300 citations

Impaired lymphocyte function in depressive illness

1983 • 280 citations

Cytokine Production and Serum Proteins in Depression

1995 • 248 citations

Α Review on the Acute Phase Response in Major Depression

1993 • 227 citations

Regulation of the Human Serotonin Transporter by Interleukin-1β

1995 • 156 citations

Changes in Acute-Phase Proteins during Lithium Potentiation of Antidepressants in Refractory Depression

1997 • 136 citations

Depression : neurobiological, psychopathological, and therapeutic advances

1997 • 136 citations

Inhibitors of serotonin synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo.

1994 • 131 citations

Low natural killer cytotoxicity in major depression

1987 • 112 citations

Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression.

1996 • 99 citations

Stimulation of splenic T-lymphocyte function by endogenous serotonin and by low-dose exogenous serotonin.

1993 • 95 citations

Serotonin regulation of T-cell subpopulations and of macrophage accessory function.

1995 • 90 citations

Serotonin inhibition of tumor necrosis factor-α synthesis by human monocytes

1991 • 79 citations

Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response

1997 • 76 citations

Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism

1996 • 70 citations

Mechanism of Inhibition

1975 • 68 citations

Serotonergic 5‐HT_1a Receptors Regulate a Cell Contact‐Mediated Interaction between Natural Killer Cells and Monocytes

1993 • 61 citations

Elevated Plasma Concentrations of α1-Acid Glycoprotein, a Putative Endogenous Inhibitor of the Tritiated Imipramine Binding Site, in Depressed Patients

1990 • 60 citations

Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer’s disease (DAT): Lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT

1998 • 59 citations

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

1996 • 55 citations

Delayed-type hypersensitivity initiation by early-acting cells that are antigen mismatched or MHC incompatible with late-acting, delayed-type hypersensitivity effector T cells.

1991 • 53 citations

Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells

1984 • 53 citations

The in vitro immunosuppressive effects of moclobemide in healthy volunteers

2000 • 50 citations

Role of Serotonin in the Regulation of Interferon-γ Production by Human Natural Killer Cells

1993 • 50 citations

Effects of interferon-?, interleukin-1?, and tumor necrosis factor-? on the serotonin metabolism in the nucleus raphe dorsalis of the rat

1997 • 50 citations

Serotonin reuptake inhibitors reverse the impairments in behaviour, neurotransmitter and immune functions in the olfactory bulbectomized rat

1994 • 40 citations

The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression

1995 • 35 citations

Increased levels of alpha‐1‐acid glycoprotein and interleukin‐6 in refractory depression

1995 • 29 citations

Influence of some drugs on the immune response. I. The effect of 5-hydroxytryptophan, iproniazid and reserpine on primary and secondary immune responses

1968 • 18 citations

Serotonin-immune interactions in detoxified chronic alcoholic patients without apparent liver disease: activation of the inflammatory response system and lower plasma total tryptophan

1998 • 17 citations

Modification of ligand binding to membranes by a soluble acceptor

1986 • 13 citations

Inhibition of platelet [3H]-imipramine binding by human plasma protein fractions

1988 • 11 citations

Inhibition of 3H-imipramine binding by plasma from depressed and normal subjects

1986 • 11 citations

Serotonin antibodies in relation to immune activation in major depression

1997 • 8 citations

Relationships between lower plasma L-tryptophan levels and immune variables in depression

1993 • 7 citations