An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily

1991 • 958 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

1990 • 528 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily.

1990 • 483 citations

Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex

1991 • 464 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

1986 • 427 citations

The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins

1990 • 417 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.

1990 • 408 citations

Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.

1991 • 404 citations

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

1992 • 404 citations

MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1

1993 • 383 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor

1985 • 369 citations

Identification of Ets- and Notch-Related Subunits in GA Binding Protein

1991 • 358 citations

glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins

1989 • 345 citations

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

1992 • 334 citations

The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.

1993 • 317 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.

1993 • 285 citations

The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

1988 • 281 citations

elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints

1989 • 261 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

1993 • 228 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.

1991 • 203 citations

Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans

1989 • 201 citations

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.

1990 • 192 citations

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.

1990 • 189 citations

Evolutionarily conserved Ets family members display distinct DNA binding specificities.

1992 • 175 citations

The erg gene: a human gene related to the ets oncogene.

1987 • 164 citations

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

1991 • 124 citations

Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene.

1988 • 122 citations

A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells

1992 • 113 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

Isoforms of the human ets-1 protein: generation by alternative splicing and differential phosphorylation.

1990 • 101 citations

The proto-oncogene c-ets is preferentially expressed in lymphoid cells.

1985 • 98 citations

Forskolin inducibility and tissue-specific expression of the fibronectin promoter.

1989 • 91 citations

The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors

1992 • 84 citations

The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter.

1991 • 76 citations

Remodeling of the Lung in Bleomycin-induced Pulmonary Fibrosis in the Rat: An Immunohistochemical Study of Laminin, Type IV Collagen, and Fibronectin

1990 • 76 citations

A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B inDrosophila melanogaster

1989 • 73 citations

Transactivation of GATA-1 promoter with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins: stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody.

1993 • 68 citations

Characterization of the alpha 4 integrin gene promoter.

1991 • 64 citations

Expression of C-ETS1 in Early Chick Embryo Mesoderm: Relationship to the Hemangioblastic Lineage

1993 • 60 citations

Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule.

1991 • 57 citations

Identity between the novel integrin β7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine

1991 • 37 citations

Interaction of a Common Factor with ATF, Spl, or TATAA Promoter Elements Is Required for These Sequences To Mediate Transactivation by the Adenoviral Oncogene E1a

1992 • 33 citations

Requirement of an ETS-binding element for transcription of the human lck type I promoter.

1993 • 32 citations

Cellular Fibronectin in Rheumatoid Synovium and Synovial Fluid: a Possible Factor Contributing to Lymphocytic Infiltration

1990 • 32 citations

Multiple Domains for the Chicken Cellular Sequences Homologous to the v-ets Oncogene of the E26 Retrovirus

1987 • 26 citations

Endotoxin‐induced endothelial injury and subendothelial accumulation of fibronectin in rat aorta

1991 • 24 citations

Thrombin stimulation of synthesis and secretion of fibronectin by human A549 epithelial cells and mouse LB fibroblasts.

1991 • 21 citations

Characterization and Uses of Monoclonal Antibody Derived Against DNA Binding Domain of the ETS Family of Genes

1992 • 12 citations

Modulation of endothelial fibronectin synthesisby polymorphonuclear granulocytes

1989 • 8 citations

Monoclonal Antibodies Specific to Human ETS-2 Oncoprotein: Recognition of Epitopes Clustered on the B Domain

1990 • 8 citations