Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

1992 • 1,258 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

An electrophoretic study of the low-molecular-weight components of myosin

1970 • 706 citations

Calcium-Binding Proteins

1976 • 479 citations

Expression and characterization of calmodulin-activated (type I) adenylylcyclase

1991 • 435 citations

Purification of the (Ca2+-Mg2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column.

1979 • 426 citations

Activation of skeletal muscle myosin light chain kinase by calcium(2+) and calmodulin

1980 • 326 citations

Comparison of the crystal and solution structures of calmodulin and troponin C

1988 • 322 citations

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase

1986 • 319 citations

Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase.

1985 • 302 citations

Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

1988 • 258 citations

The central helix of calmodulin functions as a flexible tether.

1988 • 245 citations

The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.

1987 • 241 citations

The interaction of calmodulin with amphiphilic peptides.

1985 • 239 citations

Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin.

1992 • 213 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Calcium binding to complexes of calmodulin and calmodulin binding proteins

1985 • 152 citations

Stimulation of the purified erythrocyte Ca2+-ATPase by tryptic fragments of calmodulin.

1984 • 151 citations

Melittin binding causes a large calcium-dependent conformational change in calmodulin.

1989 • 141 citations

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane calcium pump

1990 • 137 citations

Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle x-ray scattering

1985 • 135 citations

Structure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution.

1991 • 123 citations

Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase

1989 • 118 citations

Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase.

1985 • 108 citations

Structure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution.

1991 • 107 citations

Restoration of the calcium binding activity of mutant calmodulins toward normal by the presence of a calmodulin binding structure

1991 • 103 citations

Structure and sequence of the Drosophila melanogaster calmodulin gene

1987 • 100 citations

Small-angle x-ray scattering study of calmodulin bound to two peptides corresponding to parts of the calmodulin-binding domain of the plasma membrane calcium pump

1991 • 95 citations

Spatial requirements for location of basic residues in peptide substrates for smooth muscle myosin light chain kinase.

1985 • 88 citations

Binding of Both Ca2+ and Mastoparan to Calmodulin Induces a Large Change in the Tertiary Structure

1989 • 75 citations

Use of site-directed mutations in the individual Ca2(+)-binding sites of calmodulin to examine Ca2(+)-induced conformational changes.

1991 • 73 citations

Calmodulin activation of target enzymes. Consequences of deletions in the central helix.

1990 • 65 citations

Circular dichroism studies on calcium binding to two series of calcium binding site mutants of Drosophila melanogaster calmodulin

1992 • 62 citations

Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase.

1991 • 62 citations

Interaction of calmodulin with skeletal muscle myosin light chain kinase

1981 • 61 citations

Computational and site‐specific mutagenesis analyses of the asymmetric charge distribution on calmodulin

1989 • 55 citations

Toward a Model of the Calmodulin-Myosin Light-Chain Kinase Complex

1988 • 54 citations

A series of point mutations reveal interactions between the calcium‐binding sites of calmodulin

1992 • 53 citations

Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.

1990 • 46 citations

Effects of calcium binding on the internal dynamic properties of bovine brain calmodulin, studied by NMR and optical spectroscopy

1992 • 45 citations

Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes.

1985 • 44 citations

Calcium-induced Shape Change of Calmodulin with Mastoparan Studied by Solution X-ray Scattering

1989 • 42 citations

Calcium binding properties of beef cardiac troponin.

1978 • 34 citations

Stimulation of the erythrocyte Ca²⁺‐ATPase and of bovine brain cyclic nucleotide phosphodiesterases by chemically modified calmodulin

1987 • 32 citations

Acidic residues comprise part of the myosin light chain-binding site on skeletal muscle myosin light chain kinase.

1990 • 26 citations

Regulation of the erythrocyte Ca(2+)-ATPase by mutant calmodulins with Glu—-Ala substitutions in the Ca(2+)-binding domains.

1992 • 21 citations

Myosin light chain kinase binding to plastic

1982 • 16 citations

Calcium binding site mutants of calmodulin adopt abnormal conformations in complexes with model target peptides.

1993 • 13 citations

Fluorescent adducts of wheat calmodulin implicate the amino-terminal region in the activation of skeletal muscle myosin light chain kinase.

1990 • 13 citations