Pathways of Neurosteroid Biosynthesis in Cell Lines from Human Brain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1998 • 658 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

1998 • 444 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

NTera 2 Cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell

1993 • 435 citations

Peripheral-Type Benzodiazepine/Diazepam Binding Inhibitor Receptor: Biological Role in Steroidogenic Cell Function*

1993 • 404 citations

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1993 • 402 citations

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

1989 • 372 citations

Neurosteroids: Cytochrome P-450 _scc in Rat Brain

1987 • 362 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats.

1993 • 344 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

1996 • 321 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

1997 • 299 citations

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

1987 • 294 citations

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

1996 • 291 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Peripheral Benzodiazepine Receptor (PBR) in Human Breast Cancer

2003 • 283 citations

Neurosteroids: biochemistry, modes of action, and clinical relevance.

1994 • 271 citations

Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states

1997 • 269 citations

Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function

1993 • 257 citations

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

1997 • 245 citations

Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins

1986 • 239 citations

Targeted Disruption of the Peripheral-type Benzodiazepine Receptor Gene Inhibits Steroidogenesis in the R2C Leydig Tumor Cell Line

1997 • 224 citations

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

1995 • 224 citations

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

1998 • 216 citations

A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brain

1995 • 207 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

1995 • 191 citations

Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves

1986 • 184 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

1993 • 179 citations

Dehydroepiandrosterone: Biosynthesis and Metabolism in the Brain

1999 • 177 citations

Activation of Macrophages by Alzheimer β Amyloid Peptide

1994 • 175 citations

Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation.

1995 • 175 citations

Neurosteroids: Biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain

1991 • 167 citations

?-Amyloid protein enhances macrophage production of oxygen free radicals and glutamate

1997 • 165 citations

Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain

1995 • 165 citations

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

1994 • 151 citations

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

1995 • 149 citations

β-Amyloid of Alzheimer's Disease Induces Reactive Gliosis That Inhibits Axonal Outgrowth

1993 • 148 citations

Neurosteroids: biochemistry, modes of action, and clinical relevance

1994 • 137 citations

Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain

1987 • 134 citations

Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam.

1997 • 126 citations

Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17 and 3β-HSD in the postnatal rat brain

1998 • 120 citations

Localization of 17beta-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog.

1996 • 117 citations

Immunoreactive cytochrome P-45017 in rat and guineapig gonads, adrenal glands and brain

1991 • 113 citations

In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides.

1996 • 110 citations

Biosynthesis and assay of neurosteroids in rats and mice: Functional correlates

1995 • 109 citations

Neurosteroidogenesis in Rat Retinas

1994 • 109 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system

1995 • 96 citations

Potential Use of Iron Chelators against Oxidative Damage

1996 • 86 citations

Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.

1992 • 80 citations

Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function

1993 • 76 citations

Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c‐met genes in human glioma cells in vitro

1995 • 73 citations

Immunocytochemical Localization of 5α-Reductase in Rat Brain

1994 • 73 citations

Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells

1998 • 71 citations

Increase in ?3 (Peripheral-Type Benzodiazepine) binding site densities in different types of human brain tumours

1992 • 70 citations

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

1997 • 60 citations

Reversal of behavioral effects of pentylenetetrazol by the neuroactive steroid ganaxolone.

1998 • 60 citations

Precursors of the neurosteroids.

1994 • 55 citations

PERIPHERAL-TYPE BENZODIAZEPINE BINDING IN ALZHEIMER DISEASE

1988 • 48 citations

beta-Amyloid peptide induced cytoskeletal reorganization in cultured astrocytes.

1997 • 47 citations

Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress

1992 • 47 citations

Presumptive neurons derived by differentiation of a human embryonal carcinoma cell line exhibit tetrodotoxin-sensitive sodium currents and the capacity for regenerative responses

1989 • 42 citations

?-Amyloid peptide induced cytoskeletal reorganization in cultured astrocytes

1997 • 39 citations

In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides

1996 • 37 citations

Neurosteroids: Steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade

1989 • 37 citations

Establishment of a human oligodendroglial cell line

1979 • 36 citations

Aberrant splicing of rat steroid 17α-hydroxylase transcripts

1995 • 15 citations

Inhibition of adrenocortical, mitochondrial and microsomal monooxygenases by SU-10'603, a steroid 17α-hydroxylase inhibitor

1989 • 7 citations

Proceedings: Effects of aminoglutethimide and SU 10'603 on the biosynthesis of C19 steroids.

1974 • 1 citations