Reversal of behavioral effects of pentylenetetrazol by the neuroactive steroid ganaxolone.

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Anesthetic Effect of Steroid Hormones.

1941 • 363 citations

Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.

1994 • 343 citations

Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?

1987 • 329 citations

Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.

1990 • 328 citations

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1989 • 320 citations

Anxiolytic activity of an endogenous adrenal steroid

1986 • 317 citations

Modulation of the GABA_A receptor by depressant barbiturates and pregnane steroids

1988 • 296 citations

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

1987 • 288 citations

Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.

1989 • 266 citations

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

1997 • 245 citations

Neurosteroid regulation of GABAA receptor single‐channel kinetic properties of mouse spinal cord neurons in culture.

1992 • 241 citations

Neurosteroids and GABA, receptor function

1995 • 210 citations

Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.

1990 • 210 citations

Modulation of GABA_A receptor activity by alphaxalone

1987 • 196 citations

GABA-dependent modulation of the Cl− ionophore by steroids in rat brain

1987 • 188 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Behavioral analogues of anxiety animal models

1983 • 180 citations

Potentiation of gamma‐aminobutyric‐acid‐activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.

1987 • 169 citations

A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons.

1995 • 157 citations

Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents

1995 • 149 citations

Actions of synthetic and endogenous steroids on the GABAA receptor

1987 • 146 citations

Animal models of drug withdrawal symptoms

1990 • 139 citations

Subjective and discriminative effects of drugs

1991 • 135 citations

Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam.

1997 • 126 citations

Drug discrimination by humans compared to nonhumans: current status and future directions

1993 • 119 citations

Drug discrimination analysis of endogenous neuroactive steroids in rats

1993 • 114 citations

Metrazol tolerance in a “normal” volunteer population

1958 • 91 citations

Evidence that gaba mechanisms mediate the anxiolytic action of benzodiazepines: A study with valproic acid

1980 • 78 citations

Generalization and antagonism studies with convulsant, GABAergic and anticonvulsant drugs in rats trained to discriminate pentylenetetrazol from saline

1980 • 63 citations

Anxiolytic activity of steroid anesthetic alphaxalone.

1991 • 56 citations

Chapter 6. Interoceptive Discriminative Stimuli in the Development of CNS Drugs and a Case of an Animal Model of Anxiety

1980 • 52 citations

Modulation of the GABAA receptor by steroids

1991 • 45 citations

Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.

1988 • 40 citations

The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action.

1991 • 37 citations

Evidence for the role of brain norepinephrine and dopamine in “rebound” phenomenon seen during withdrawal after repeated exposure to benzodiazepines

1977 • 37 citations

5α-pregnan-3α-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition

1990 • 29 citations

The role of GABA in the anticonflict action of sodium valproate and chlordiazepoxide

1984 • 28 citations

Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid

1993 • 19 citations

Relationship of the behavioral effects of aprophen, atropine and scopolamine to antagonism of the behavioral effects of physostigmine

1990 • 17 citations

Relationships between hyponeophagia, diazepam sensitivity and benzodiazepine receptor binding in eighteen rat genotypes

1984 • 17 citations

GABA-stimulated 36Cl- flux in brain slices as an assay for modulation by CNS depressant drugs.

1988 • 2 citations

Neuroactive steroids as a treatment for epilepsy. Current status and future directions

1997 • 2 citations