Instrumental role of Na+ in NMDA excitotoxicity in glucose‐deprived and depolarized cerebellar granule cells
Data up to Jan 2025
Total Citations Per Year
Abstract
References (55)
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
1985 • 21,873 citations
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
1984 • 2,884 citations
Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination
1993 • 2,272 citations
Ionic dependence of glutamate neurotoxicity
1987 • 1,811 citations
Sodium/Calcium Exchange: Its Physiological Implications
1999 • 1,690 citations
Isozymes of the Na+/K+-ATPase
1989 • 955 citations
Extracellular space structure revealed by diffusion analysis
1998 • 876 citations
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
1993 • 569 citations
The Na,K-ATPase
1992 • 552 citations
Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex
1981 • 538 citations
A Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX1
1996 • 506 citations
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration
1993 • 396 citations
Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger
1994 • 353 citations
Cloning of a Third Mammalian Na+-Ca2+ Exchanger, NCX3
1996 • 347 citations
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
2001 • 337 citations
A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea‐pig cardiac ventricular cells
1996 • 300 citations
Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity
1998 • 270 citations
Ion Homeostasis in Rat Brain in vivo: Intra- and Extracellular [Ca2+] and [H+] in the Hippocampus during Recovery from Short-Term, Transient Ischemia
1992 • 234 citations
Activation of (Na+, K+)‐ATPase by Nanomolar Concentrations of GM1 Ganglioside
1981 • 212 citations
Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells
1997 • 201 citations
Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells
1998 • 199 citations
Glutamate impairs neuronal calcium extrusion while reducing sodium gradient
1994 • 172 citations
The extracellular potassium concentration in brain cortex following ischemia in hypo‐ and hyperglycemic rats
1978 • 171 citations
Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.
1997 • 169 citations
The Quantity of Calcium that Appears to Induce Neuronal Death
1994 • 167 citations
Differential inhibition of Na+/Ca2+exchanger isoforms by divalent cations and isothiourea derivative
1998 • 160 citations
Role of Phosphate and Other Proton-Donating Anions in Respiration-Coupled Transport of Ca 2+ by Mitochondria
1974 • 158 citations
Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger
1992 • 157 citations
Molecular Cloning of a Third Member of the Potassium-dependent Sodium-Calcium Exchanger Gene Family,NCKX3
2001 • 157 citations
Ca2+-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca2+Influx Underlies Potent Induction of Injury
1996 • 156 citations
Synaptosomal bioenergetics
1986 • 149 citations
Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators
1997 • 149 citations
Gain control of NMDA-receptor currents by intracellular sodium
1998 • 148 citations
Reverse Na+/Ca2+Exchange Contributes to Glutamate-Induced Intracellular Ca2+Concentration Increases in Cultured Rat Forebrain Neurons
1998 • 136 citations
Enzymatic properties of separated isozymes of the Na,K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry.
1985 • 127 citations
Molecular Cloning of a Novel Potassium-dependent Sodium-Calcium Exchanger from Rat Brain
1998 • 124 citations
Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures
1991 • 122 citations
Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering.
1995 • 113 citations
Na+—Ca2+ Exchange Currents in Cortical Neurons: Concomitant Forward and Reverse Operation and Effect of Glutamate
1997 • 100 citations
N-methyl-d-aspartate Excitotoxicity: Relationships among Plasma Membrane Potential, Na+/Ca2+Exchange, Mitochondrial Ca2+Overload, and Cytoplasmic Concentrations of Ca2+, H+, and K+
1999 • 92 citations
Ionic selectivity of low-affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC
2000 • 91 citations
Calcineurin Controls the Transcription of Na+/Ca2+ Exchanger Isoforms in Developing Cerebellar Neurons
2000 • 90 citations
Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB-R7943
1999 • 88 citations
Cloning of two isoforms of the rat brain Na+Ca+ exchanger gene and their functional expression in HeLa cells
1993 • 87 citations
The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury
1999 • 84 citations
Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus
2001 • 78 citations
Structural Domains Influencing Sensitivity to Isothiourea Derivative Inhibitor KB-R7943 in Cardiac Na+/Ca2+Exchanger
2001 • 77 citations
Exacerbated Responses to Oxidative Stress by an Na+Load in Isolated Nerve Terminals: the Role of ATP Depletion and Rise of [Ca2+]i
2000 • 72 citations
Voltage‐gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick.
1990 • 51 citations
Ion permeation properties of the cloned mouse ϵ2/ζ1 NMDA receptor channel
1994 • 46 citations
Inactivation of calcium currents in granule cells cultured from mouse cerebellum.
1991 • 45 citations
Na+/H+ exchange in mitochondria as monitored by BCECF fluorescence
1989 • 26 citations
Elevated extracellular K(+) concentrations inhibit N-methyl-D-aspartate-induced Ca(2+) influx and excitotoxicity.
1999 • 13 citations
Kainate-induced K+ efflux and plasma membrane depolarization in cultured cerebellar granule cells
2001 • 7 citations
Repolarization of the plasma membrane shapes NMDA-induced cytosolic [Ca2+] transients
2001 • 3 citations