Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells

Brain energy metabolism

1978 • 1,448 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

The Sodium Pump

1975 • 969 citations

ATP and Brain Function

1989 • 812 citations

Mechanosensitive ion channels

1990 • 721 citations

Metabolic regulation via intracellular pH

1984 • 674 citations

Protons and Anaerobiosis

1983 • 572 citations

A simple analysis of the "phosphocreatine shuttle"

1984 • 503 citations

Ions and energy in mammalian brain

1994 • 470 citations

The (Na+ + K+)-activated ATPase Enzymatic and transport properties

1979 • 401 citations

Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo.

1990 • 386 citations

Activation of ion transport pathways by changes in cell volume

1991 • 306 citations

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

1991 • 265 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Ion Homeostasis in Rat Brain in vivo: Intra- and Extracellular [Ca²⁺] and [H⁺] in the Hippocampus during Recovery from Short-Term, Transient Ischemia

1992 • 234 citations

Glial Glycogen Stores Affect Neuronal Survival during Glucose Deprivation in vitro

1993 • 233 citations

Function of astroglia in the water‐ion metabolism of the central nervous system

1959 • 231 citations

Characterization of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in primary cultures of mouse cerebral cortical astrocytes

1991 • 231 citations

Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis.

1989 • 230 citations

Cytochemical identification of cerebral glycogen and glucose‐6‐phosphatase activity under normal and experimental conditions: I. Neurons and glia

1986 • 196 citations

Brain Tissue Electrolytes

1967 • 144 citations

The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801

1992 • 140 citations

Cellular events during partial cerebral ischemia

1977 • 136 citations

Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o

1993 • 134 citations

Role of ATP‐sensitive K+ channels during anoxia: major differences between rat (newborn and adult) and turtle neurons.

1992 • 125 citations

Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures

1988 • 124 citations

Baroreceptor mechanisms at the cellular level.

1987 • 111 citations

Glycogen and its Related Enzymes of Metabolism in the Central Nervous System

1975 • 108 citations

Energy‐dependent volume regulation in primary cultured cerebral astrocytes

1986 • 107 citations

Anoxia induces an increase in intracellular sodium in rat central neurons in vitro

1994 • 107 citations

Modulation of calcium current, intracellular calcium levels and cell survival by glucose deprivation and growth factors in hippocampal neurons

1993 • 100 citations

Glycolysis and brain function: [K+]o stimulation of protein synthesis and K+ uptake require glycolysis.

1983 • 99 citations

Effects of Antimycin, Glucose Deprivation, and Serum on Cultures of Neurons, Astrocytes, and Neuroblastoma Cells

1985 • 96 citations

Association of glycolytic enzymes with particulate fractions from nerve endings

1978 • 94 citations

Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes

1994 • 80 citations

The nature of fuel provision for the Na+,K(+)‐ATPase in porcine vascular smooth muscle.

1992 • 79 citations

Glycogen in the Central Nervous System

1974 • 72 citations

Corticosterone accelerates hypoxia- and cyanide-induced ATP loss in cultured hippocampal astrocytes

1992 • 71 citations

Cell Swelling, Blebbing, and Death Are Dependent on ATP Depletion and Independent of Calcium During Chemical Hypoxia in a Glial Cell Line (ROC‐1)

1992 • 71 citations

Regulation of Glycogen Content in Primary Astrocyte Culture: Effects of Glucose Analogues, Phenobarbital, and Methionine Sulfoximine

1989 • 70 citations

Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neuronsin vitro: Effect of chemical ischemia

1994 • 70 citations

Relations between intracellular ions and energy metabolism: a study with monensin in synaptosomes, neurons, and C6 glioma cells

1991 • 68 citations

Active ion transport in the renal proximal tubule. III. The ATP dependence of the Na pump.

1984 • 68 citations

Metabolic and Biosynthetic Alterations in Cultured Astrocytes Exposed to Hypoxia/Reoxygenation

1994 • 63 citations

Ultrastucture of the central nervous system after prolonged hypoxia

1972 • 60 citations

Inhibitors of mitochondrial function

1982 • 58 citations

Correlation between content of high-energy phosphates and hypoxic-ischemic damage in immature and mature astrocytes

1994 • 54 citations

Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes

1990 • 53 citations

Effects of Extracellular Potassium on Glycogen Stores of Astrocytes In Vitro

1988 • 53 citations

Inhibitors of mitochondrial functions

1981 • 51 citations

Stretch-activated ion channels in bacteria and animal cell membranes

1987 • 50 citations

Glycolysis, Oxidative Metabolism, and Brain Potassium Ion Clearance

1992 • 48 citations

Hypoglycemic neurotoxicity in vitro: Involvement of excitatory amino acid receptors and attenuation by monosialoganglioside GM1

1990 • 47 citations

NMR spectroscopic study of cell cultures of astrocytes and neurons exposed to hypoxia: Compartmentation of astrocyte metabolism

1994 • 42 citations

Energy metabolism of renal cell lines, A6 and MDCK: regulation by Na-K-ATPase

1987 • 40 citations

Cytosolic free calcium and cell death during metabolic inhibition in a neuronal cell line

1994 • 34 citations

Relations Between Intracellular Ions and Energy Metabolism Under Acidotic Conditions: A Study with Nigericin in Synaptosomes, Neurons, and C6 Glioma Cells

1993 • 33 citations

Calcium Buffering and Free Ca²⁺ in Rat Brain Synaptosomes

1993 • 32 citations

Metabolic and Energetic Changes During Apoptosis in Neural Cells

1995 • 30 citations

Inhibition of Glycolysis Alters Potassium Ion Transport and Mitochondrial Redox Activity in Rat Brain

1988 • 29 citations

Rb⁺ influx in response to changes in energy generation: Effect of the regulation of the ATP content of HELa cells

1984 • 28 citations

Glycolysis and recovery of pottasium ion homeostasis and synaptic transmission in hippocampal slices after anoxia or stimulated pottasium release

1993 • 28 citations

The role of glial cells in regulation of neurotransmitter amino acids in the external environment. I. Transmembrane electrical and ion gradients and energy parameters in cultured glial-derived cell lines

1986 • 26 citations

Glucose Regulates Glutamate‐Evoked Arachidonic Acid Release from Cultured Striatal Neurons

1995 • 24 citations

Glycolysis can prevent non-synaptic excitatory amino acid release during hypoxia

1994 • 23 citations

Ultrastructure of the central nervous system after prolonged hypoxia

1972 • 20 citations

Quantitative requirement for ATP for active transport in isolated renal cells

1986 • 17 citations

Deleted Work

1955 • 0 citations