New fluorescent probes for protein kinase C. Synthesis, characterization, and application

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Mitochondrial Membrane Potential in Living Cells

1988 • 1,010 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Fluorescent phallotoxin, a tool for the visualization of cellular actin.

1979 • 781 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

A synthetic peptide substrate for selective assay of protein kinase C

1990 • 292 citations

Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity

1992 • 217 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters.

1992 • 160 citations

Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic stimulation of pineal cAMP and cGMP by K+ and A23187.

1988 • 130 citations

Immunochemical characterization of rat brain protein kinase C.

1986 • 110 citations

The mechanism of activation of protein kinase C: a biophysical perspective

1992 • 94 citations

Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene.

1989 • 93 citations

Localized mast cell degranulation induced by concanavalin A-sepharose beads. Implications for the Ca2+ hypothesis of stimulus-secretion coupling.

1978 • 76 citations

Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts

1990 • 70 citations

Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association.

1988 • 63 citations

Synthesis of a fluorescent derivative of amethopterin

1975 • 55 citations

A mild conversion of maleic anhydrides into maleimides

1990 • 47 citations

Immunocytochemical evidence for phorbol ester-induced directional translocations of protein kinase C in HL60, K562, CHO, and E7SKS cells: possible role in differentiation.

1987 • 42 citations

A convenient synthesis of bisindolyl- and indolylaryl maleic anhydrides

1990 • 38 citations

Cellular uptake and localization of fluorescent derivatives of phorbol ester tumor promoters

1985 • 34 citations

Altered regulation of a major substrate of protein kinase C in rat 6 fibroblasts overproducing PKC beta I.

1992 • 24 citations

Intracellular localization of 12-O-3-N-dansylamino TPA in C3H/10T1/2 mouse cell line

1985 • 22 citations

Biosynthesis of paf-acether. Activators of protein kinase C stimulate cultured mast cell acetyltransferase without stimulating paf-acether synthesis

1990 • 14 citations

Fluorescent tetradecanoylphorbol acetate: A novel probe of phorbol ester binding domains

1991 • 11 citations

A Fluorescent Protein Kinase C Inhibitor: 1-(1-Hydroxy-5-isoquinolinylsulfonyl)piperazine

1988 • 8 citations

Selective labeling of α-bungarotoxin with fluorescein isothiocyanate and its use for the study of toxin-acetylcholine receptor interactions

1990 • 5 citations