The Precise and Entire Antigenic Structure of Lysozyme: Implications of Surface-Simulation Synthesis and the Molecular Features of Protein Antigenic Sites

Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution

1965 • 1,623 citations

The Amino Acid Sequence of Egg White Lysozyme

1963 • 726 citations

Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins

1975 • 474 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

21 Vertebrate Lysozymes

1972 • 358 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

The Disulfide Bonds of Egg White Lysozyme (Muramidase)

1965 • 258 citations

La structure chimique du lysozyme de blanc d'oeuf de poule: étude détaillée

1963 • 253 citations

Conversion of 3-nitrotyrosine to 3-aminotyrosine in peptides and proteins

1967 • 252 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Immunochemistry of sperm whale myoglobin. I. Specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen

1968 • 200 citations

[49] Reaction of proteins with citraconic anhydride

1972 • 177 citations

Antibodies Reactive with Native Lysozyme Elicited by a Completely Synthetic Antigen

1971 • 172 citations

PEPTIDES DERIVED FROM TRYPTIC DIGESTION OF EGG WHITE LYSOZYME.

1963 • 171 citations

Peptides Derived from Tryptic Digestion of Egg White Lysozyme

1963 • 140 citations

Enzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagents

1970 • 134 citations

ANTIBODIES TO A UNIQUE REGION IN LYSOZYME PROVOKED BY A SYNTHETIC ANTIGEN CONJUGATE

1969 • 124 citations

Immunochemistry of sperm-whale myoglobins prepared with various modified porphyrins and metalloporphyrins

1967 • 118 citations

Immunochemistry of sperm-whale myoglobin

1973 • 109 citations

Human Platelet Myosin

1971 • 106 citations

Immunochemistry of sperm-whale myoglobin—XVI: Accurate delineation of the single region in sequence 1–55 by immunochemical studies of synthetic peptides. Some conclusions concerining antigenic structures of proteins

1974 • 104 citations

Enzymic and immunochemical properties of lysozyme. I. Derivatives modified at tyrosine. Influence of nature of modification on activity

1969 • 98 citations

Immunochemistry of sperm whale myoglobin. IV. Role of the arginine residues in the conformation and differentiation of their roles in the antigenic reactivity

1969 • 90 citations

Lack of immunochemical cross-reaction between lysozyme and α-lactalbumin and comparison of their conformations

1970 • 83 citations

Studies on the Antigenic Structure of Ribonuclease

1962 • 81 citations

Immunochemistry of sperm whale myoglobin VI. Preparation and conformational analysis of eight mammalian myoglobins

1970 • 74 citations

Enzymic and immunochemical properties of lysozyme

1971 • 72 citations

Immunochemistry of sperm whale myoglobin. III. Modification of the three tyrosine residues and their role in the conformation and differentiation of their roles in the antigenic reactivity

1968 • 70 citations

Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by ‘surface simulation’ synthesis

1977 • 69 citations

Immunochemical studies on lysozyme and carboxymethylated lysozyme

1970 • 69 citations

Enzymic and immunochemical properties of lysozyme XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site

1976 • 68 citations

Self-Association and Allosteric Properties of Glutamine-dependent Carbamyl Phosphate Synthetase

1974 • 66 citations

Immunochemistry of sperm-whale myoglobin

1974 • 66 citations

Immunochemistry of Proteins

1979 • 64 citations

Delineation of the third antigenic site of lysozyme by application of a novel ‘surface-simulation’ synthetic approach directly linking the conformationally adjacent residues forming the site

1976 • 63 citations

Enzymic and immunochemical properties of lysozyme — II.

1969 • 60 citations

Antigenic properties of egg-white lysozyme. I. Isolation and characterization of a tryptic peptide from reduced and alkylated lysozyme exhibiting haptenic activity

1968 • 59 citations

Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin

1977 • 58 citations

Specific receptors of antibodies, antigens and cells

1973 • 57 citations

Immunochemistry of sperm-whale myoglobin--XXII. Accurate delineation of the single reactive region in sequence 103-120 by immunochemical studies of synthetic peptides: the complete antigenic structure of the protein.

1975 • 55 citations

Conformational Studies on Modified Proteins and Peptides

1971 • 54 citations

A fragment comprising the last third of bovine serum albumin which accounts for almost all the antigenic reactivity of the native protein.

1976 • 54 citations

The Complete Antigenic Structure of Myoglobin: Approaches and Conclusions for Antigenic Structures of Proteins

1977 • 54 citations

Enzymic and immunochemical properties of lysozyme

1973 • 52 citations

Lysozymes characterized in Duck Egg-white: Isolation of a Histidine-less Lysozyme

1965 • 49 citations

Immunochemistry of sperm whale myoglobin VII. Correlation of immunochemical cross-reaction of eight myoglobins with structural similarity and its dependence on conformation

1970 • 48 citations

Enzymic and immunochemical properties of lysozyme—V derivatives modified at lysine residues by guanidination, acetylation, succinylation or maleylation

1971 • 48 citations

IMMUNOCHEMICAL REACTIONS INVOLVING RIBONUCLEASE*

1959 • 46 citations

Immunochemistry of sperm-whale myoglobin—XX: Accurate delineation of the single reactive region in sequence 80–103 by immunochemical studies of synthetic peptides

1975 • 45 citations

Reaction of β-propiolactone with amino acids and its specificity for methionine

1968 • 44 citations

Immunochemistry of sperm-whale myoglobin—XXII

1975 • 43 citations

Conformational studies on modified proteins and peptides. VI. Conformation and immunochemistry of methylated and carboxymethylated derivatives of lysozyme

1973 • 41 citations

Immunochemistry of serum albumin—II

1976 • 39 citations

Enzymic and immunochemical properties of lysozyme

1977 • 39 citations

The Antigenic Structure of Hen Egg-White Lysozyme: A Model for Disulfide-Containing Proteins

1977 • 37 citations

Enzymic and immunochemical properties of lysozyme—XII Delineation of the reactive site around the two central disulfides by immunochemical and conformational studies of derivatives of the two-disulfide peptide

1976 • 34 citations

Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal Autoreactivity in rabbits of antibodies to spermwhale myoglobin

1977 • 34 citations

Enzymic and immunochemical properties of lysozyme—VI Conformation, enzymic activity and immunochemistry of derivatives modified at arginine residues

1972 • 33 citations

Immunochemistry of sperm-whale myoglobin--XXIII. Investigation of the independence of the five antigenic reactive regions by immunoabsorbent studies.

1975 • 32 citations

Enzymic and immunochemical properties of lysozyme. XIII. Accurate delineation of the reactive site around the disulfide 6-127 by immunochemical study of β-propiolactone lysozyme derivative and of synthetic disulfide peptides

1976 • 30 citations

Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins

1977 • 29 citations

Immunochemistry of sperm whale myoglobin—V. Specific modification of the methionine residues with β-propiolactone

1969 • 27 citations

Immunochemistry of sperm-whale myoglobin—XXIII

1975 • 27 citations

Preparation and properties of crystals of a Bence-Jones dimer with mercury inserted into the interchain disulfide bond

1973 • 25 citations

Enzymic and immunochemical properties of lysozyme

1975 • 25 citations

Enzymic and immunochemical properties of lysozyme

1975 • 24 citations

Studies on the b-type cytochromes from mung bean seedlings. IV. Purification and properties of cytochrome b3 (b-559).

1963 • 24 citations

Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme.

1977 • 23 citations

Peptides with strong immunochemical inhibitory activity from bovine serum albumin. Application of a novel approach

1974 • 23 citations

Reaction of myoglobin with 3,3-tetramethyleneglutaric anhydride

1967 • 18 citations

Immunochemistry of sperm-whale myoglobin—XXI

1975 • 17 citations

2,3-dioxo-5-indolinesulfonic acid, a new highly specific reagent for modification of tryptophan in peptides and proteins

1975 • 17 citations

Enzymic and immunochemical properties of lysozyme—VIII. Modification of two carboxyl groyps and their role in the antigenic reactivity

1974 • 15 citations

Enzymic and immunochemical properties of lysozyme

1975 • 15 citations

Conformation, enzymic activity, and immunochemistry of a lysozyme derivative modified at tryptophan 123 by reaction with 2,3-dioxo-5-indolinesulfonic acid.

1976 • 13 citations

Conformation of Lysozyme Derivatives Modified at Two Carboxyl Groups

1974 • 13 citations

Amino acid composition of duck and turkey egg-white lysozymes.

1966 • 9 citations

Immunogenicity and antigenic specificity of the loop fragment of lysozyme

1974 • 7 citations