Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin.

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

A clinical trial of anti-idiotype therapy for B cell malignancy

1985 • 434 citations

Ribosome‐inactivating proteins up to date

1986 • 390 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

Myeloma Proteins as Tumor-Specific Transplantation Antigens

1972 • 325 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Emergence of Idiotype Variants during Treatment of B-Cell Lymphoma with Anti-Idiotype Antibodies

1985 • 257 citations

Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma

1982 • 243 citations

Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)

1983 • 225 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium.

1982 • 150 citations

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.

1987 • 134 citations

An Immunotoxin Composed of Monoclonal Anti-Thy 1.1 Antibody and a Ribosome-Inactivating Protein From <italic>Saponaria officinalis:</italic> Potent Antitumor Effects In Vitro and In Vivo

1985 • 130 citations

Antibody to a molecularly-defined antigen confined to a tumour cell surface

1975 • 128 citations

Cytotoxicity Acquired by Conjugation of an Anti‐Thy_1.1 Monoclonal Antibody and the Ribosome‐Inactivating Protein, Gelonin

1981 • 122 citations

In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins.

1982 • 122 citations

Study of the plasma clearance of antibody – ricin‐A‐chain immunotoxins

1986 • 116 citations

Mutations in Immunoglobulin-Producing Moose Myeloma Cells

1973 • 99 citations

Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors

1986 • 97 citations

Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes: a therapeutic target.

1977 • 90 citations

Neoplastic B Cells as Targets for Antibody‐Ricin A Chain Immunotoxins

1982 • 85 citations

Somatic mutation gains its place among the generators of diversity

1981 • 84 citations

Spontaneous Alteration of Idiotype in a Monoclonal B-Cell Lymphoma

1985 • 81 citations

L2C Guinea Pig Lymphatic Leukemia: A "B" Cell Leukemia

1972 • 80 citations

In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. In vivo stability of disulfide-linked immunotoxin conjugates.

1986 • 70 citations

Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity

1983 • 70 citations

Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies.

1984 • 60 citations

Therapy of murine leukemia with monoclonal antibody against a normal differentiation antigen.

1983 • 59 citations

Immunization with idiotypic immunoglobulin protects against development of B lymphocytic leukemia, but emerging tumor cells can evade antibody attack by modulation.

1983 • 58 citations

Somatic Mutants and Antibody Diversity

1977 • 53 citations

Idiotype variant cell populations in patients with B cell lymphoma.

1986 • 52 citations

Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity.

1982 • 52 citations

Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy.

1987 • 47 citations

Antigenic modulation of lymphocytic surface immunoglobulin yielding resistance to complement-mediated lysis. II. Relationship to redistribution of the antigen.

1981 • 42 citations

Surface immunoglobulin of guinea-pig leukaemic lymphocytes.

1975 • 32 citations

Some effects on leukaemic B lymphocytes of antibodies to defined regions of their surface immunoglobulin.

1977 • 28 citations

Surface immunoglobulin of B-lymphocytic tumours as a therapeutic target.

1985 • 27 citations

Antibodies against urinary light chain idiotypes as agents for detection and destruction of human neoplastic B lymphocytes.

1983 • 20 citations

Generation of heavy chain-loss mutants in a B cell hybrid mediated by syngeneic idiotype-specific spleen cells.

1984 • 18 citations

Significance of the Kinetics of Immunotoxin Cytotoxicity

1984 • 18 citations

Consumption of monoclonal anti-idiotypic antibody by neoplastic B lymphocytes: A guide for immunotherapy

1984 • 15 citations

Immunoglobulin produced by guinea-pig leukaemic B lymphocytes: its source and use as a monitor of tumour load.

1980 • 13 citations

Inhibition of in vivo growth of murine plasmacytoma MOPC-460 by monoclonal anti-idiotypic antibodies directed at distinct idiotypes of the immunoglobulin on the surface of MOPC-460.

1984 • 13 citations

Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes

1987 • 10 citations

Further studies of immunoglobulin synthesis by guinea pig leukaemic lymphocytes.

1978 • 10 citations

Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma

1982 • 5 citations

Derivatives of Anti-Idiotype Antibodies in the Treatment of B-Cell Lymphoma

1985 • 3 citations