Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells

The Statistical Analysis of Failure Time Data.

1981 • 10,224 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Current protocols in immunology

1992 • 1,464 citations

REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

1988 • 703 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype

1989 • 356 citations

PKCALC: A Basic Interactive Computer Program for Statistical and Pharmacokinetic Analysis of Data

1986 • 301 citations

Noncompartmental Determination of the Steady-State Volume of Distribution for Any Mode of Administration

1982 • 288 citations

IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells.

1982 • 285 citations

Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies.

1989 • 255 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody.

1994 • 164 citations

Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces

1980 • 152 citations

Engineering Antibodies for Therapy

1992 • 151 citations

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.

1985 • 147 citations

Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants.

1986 • 129 citations

Antibodies as cytotoxic therapy.

1994 • 127 citations

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site‐directed mutagenesis

1994 • 117 citations

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

1988 • 116 citations

Influence of antibody isotype on passive serotherapy of lymphoma.

1985 • 112 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 98 citations

Disseminated or localized growth of a human B‐cell tumor (Daudi) in scid mice

1990 • 95 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 90 citations

p185HER2 signal transduction in breast cancer cells

1991 • 88 citations

Genetically Engineered Antibody Molecules

1989 • 81 citations

Therapy of lymphoma directed at idiotypes.

1990 • 73 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 72 citations

Monoclonal antibodies as agonists: an expanded role for their use in cancer therapy.

1994 • 69 citations

Lymphoma models for B-cell activation and tolerance

1985 • 69 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 65 citations

The GLP large scale preparation of immunotoxins containing deglycosylated ricin A chain and a hindered disulfide bond

1991 • 54 citations

Eradication of large human B cell tumors in nude mice with unconjugated CD20 monoclonal antibodies and interleukin 2.

1995 • 52 citations

A genetically engineered human IgG mutant with enhanced cytolytic activity.

1992 • 48 citations

Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells.

1988 • 46 citations

Anti-B4-blocked ricin immunotoxin shows therapeutic efficacy in four different SCID mouse tumor models.

1993 • 46 citations

Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies

1994 • 45 citations

Engineered humanized dimeric forms of IgG are more effective antibodies.

1992 • 44 citations

Integrins and other adhesion molecules involved in melanocytic tumor progression

1995 • 43 citations

Tumour dormancy and cell signalling--III: Role of hypercrosslinking of IgM and CD40 on the induction of cell cycle arrest and apoptosis in B lymphoma cells.

1995 • 37 citations

An unmodified anticarcinoma antibody, BR96, localizes to and inhibits the outgrowth of human tumors in nude mice.

1992 • 35 citations

Monoclonal antibody homodimers: enhanced antitumor activity in nude mice.

1993 • 35 citations

Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation.

1991 • 30 citations

Selective in vivo antitumor effects of monoclonal anti-I-A antibody on B cell lymphoma.

1987 • 27 citations

Enhanced antitumor effects of CD20 over CD19 monoclonal antibodies in a nude mouse xenograft model.

1995 • 23 citations

Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.

1994 • 23 citations

Efficient induction of apoptosis in cultured rat glomerular mesangial cells by dimeric monoclonal IgA anti-Thy-1 antibodies

1997 • 18 citations

Fc gamma receptor II (CD32) on malignant B cells influences modulation induced by anti-CD19 monoclonal antibody

1994 • 18 citations

Immunoconjugates and Immunotoxins for Therapy of Carcinomas

1995 • 15 citations

Effect of light chain V region duplication on IgG oligomerization and in vivo efficacy

1991 • 12 citations

Antibody-targeted lymphokine-activated killer cells inhibit liver micrometastases in severe combined immunodeficient mice

1995 • 7 citations

Section Review Biologicals & Immunologicals: The use of immunoconjugates in cancer therapy

1996 • 4 citations