T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Early establishment of a pool of latently infected, resting CD4 ⁺ T cells during primary HIV-1 infection

1998 • 811 citations

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

1999 • 369 citations

Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A

2000 • 354 citations

Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

2000 • 322 citations

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

1998 • 283 citations

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

1998 • 269 citations

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

1999 • 259 citations

Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

1998 • 224 citations

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae

1993 • 219 citations

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4⁺ and CD8⁺ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

1996 • 218 citations

Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3‘,5‘-cyclic adenosine monophosphate on cell replication in human T lymphocytes.

1992 • 186 citations

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

1999 • 141 citations

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants

1996 • 128 citations

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant

1997 • 115 citations

Alternative Splicing of the High Affinity cAMP-Specific Phosphodiesterase (PDE7A) mRNA in Human Skeletal Muscle and Heart

1997 • 110 citations

Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

1996 • 104 citations

Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography

1982 • 102 citations

Nuclear import of HIV-1 DNA in resting CD4+ T cells requires a cyclosporin A-sensitive pathway.

1997 • 55 citations

A New Cyclic Nucleotide Phosphodiesterase Isozyme Expressed in the T-Lymphocyte Cell Lines

1993 • 52 citations

Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.

1997 • 52 citations

The anti-T cell monoclonal antibody 9.3 (Anti-CD28) provides a helper signal and bypasses the need for accessory cells in T Cell activation with immobilized anti-CD3 and mitogens

1989 • 42 citations

Inhibition of Lymphocyte Stimulation by Cyclic and Non-Cyclic Nucleotides

1971 • 38 citations

Stimulation of T-cells with OKT3 antibodies increases forskolin binding and cyclic AMP accumulation

1990 • 31 citations

Assignment of the MousePde7AGene to the Proximal Region of Chromosome 3 and of the HumanPDE7AGene to Chromosome 8q13

1998 • 11 citations

Increased cAMP and cAMP-Dependent Protein Kinase Activity Mediate Anti-CD2 Induced Suppression of Anti-CD3-Driven lnterleukin-2 Production and CD25 Expression

1995 • 8 citations