C/EBPβ enhances IL-4 but impairs IL-2 and IFN-γ induction in T cells

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

1998 • 661 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice.

1995 • 418 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Recombinant NFAT1 (NFATp) Is Regulated by Calcineurin in T Cells and Mediates Transcription of Several Cytokine Genes

1996 • 192 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

1994 • 144 citations

Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells

1999 • 128 citations

Solution Structure of the Core NFATC1/DNA Complex

1998 • 107 citations

Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

1997 • 96 citations

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

1995 • 92 citations

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

1994 • 90 citations

Nuclear factor-IL6 activates the human IL-4 promoter in T cells.

1995 • 85 citations

Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell Accessory Molecule CD28

1998 • 82 citations

Th2-Specific Protein/DNA Interactions at the Proximal Nuclear Factor-AT Site Contribute to the Functional Activity of the Human IL-4 Promoter

1998 • 68 citations

HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells

1996 • 67 citations

Impaired Generation of Bone Marrow B Lymphocytes in Mice Deficient in C/EBPβ

1997 • 64 citations

Separation of C/EBPα-mediated proliferation arrest and differentiation pathways

1999 • 61 citations

Versatile Retrovirus Vector Systems for Regulated Gene Expression In Vitro and In Vivo

1997 • 58 citations

Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.

1997 • 53 citations

A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.

1993 • 47 citations

Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter

1995 • 30 citations

In vitro skewing of TCR transgenic CD4+ T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2.

1998 • 11 citations

Deleted Work

1955 • 0 citations