Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Glutathione peroxidase: A selenoenzyme

1973 • 1,358 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

1985 • 961 citations

A novel biologically active seleno-organic compound—1

1984 • 810 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

The Refined Structure of the Selenoenzyme Glutathione Peroxidase at 0.2‐nm Resolution

1983 • 676 citations

Selenium in Biology and Medicine

1989 • 586 citations

Evidence for specific selenium target tissues and new biologically important selenoproteins

1988 • 466 citations

A novel biologically active seleno-organic compound—II

1984 • 418 citations

Molecular actions of Ebselen—an antiinflammatory antioxidant

1995 • 415 citations

Ebselen, a selenoorganic compound as glutathione peroxidase mimic

1993 • 414 citations

Development of synthetic compounds with glutathione peroxidase activity

1989 • 403 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

One- and two-electron oxidations of methionine by peroxynitrite.

1994 • 318 citations

Agonist-Induced Peroxynitrite Production from Endothelial Cells

1994 • 254 citations

Probing the Presumed Catalytic Triad of Selenium-Containing Peroxidases by Mutational Analysis of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)

1995 • 247 citations

Sensitivity of the Essential Zinc-Thiolate Moiety of Yeast Alcohol Dehydrogenase to Hypochlorite and Peroxynitrite

1995 • 246 citations

Interaction of myeloperoxidase with peroxynitrite

1993 • 233 citations

The kinetics of the oxidation of l-ascorbic acid by peroxynitrite

1995 • 188 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

Expedient synthesis of ebselen and related compounds

1989 • 184 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

The Reaction of Ebselen with Peroxynitrite

1996 • 171 citations

Organoselenium chemistry. Redox chemistry of selenocysteine model systems

1987 • 170 citations

Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: Assessment of the roles of lipid peroxidation and selenoprotein P

1995 • 168 citations

Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions

1987 • 166 citations

The Amino-Acid Sequence of Bovine Glutathione Peroxidase

1984 • 162 citations

Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)

1988 • 160 citations

Primary Structure of Human Plasma Glutathione Peroxidase Deduced from eDNA Sequences1

1990 • 155 citations

Selenium-dependent glutathione peroxidase protein and activity: immunological investigations on cellular and plasma enzymes

1986 • 152 citations

Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 Å resolution

1979 • 152 citations

A novel biologically active selenoorganic compound—IV

1985 • 151 citations

Phospholipid Hydroperoxide Glutathione Peroxidase is a Seleno-Enzyme Distinct from the Classical Glutathione Peroxidase as Evident from Cdna and Amino Acid Sequencing

1991 • 150 citations

Nitration and Hydroxylation of Phenolic Compounds by Peroxynitrite

1996 • 148 citations

The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat

1995 • 146 citations

Mechanism of the Catalytic Reduction of Hydroperoxides by Ebselen : A Selenium - 77 Nmr Study

1987 • 146 citations

A novel biologically active seleno-organic compound—V

1985 • 131 citations

Studies on the anti-inflammatory activity of ebselen

1989 • 125 citations

Selenium-Containing Compounds Protect DNA fromSingle-Strand Breaks Caused by Peroxynitrite

1996 • 117 citations

A novel biologically active seleno-organic compound—VI

1986 • 109 citations

Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.

1990 • 108 citations

Reduction of HDL- and LDL-Associated Cholesterylester and Phospholipid Hydroperoxides by Phospholipid Hydroperoxide Glutathione Peroxidase and Ebselen (PZ-51)

1994 • 106 citations

Benzoselenazolinone Derivatives Designed To Be Glutathione Peroxidase Mimetics Feature Inhibition of Cyclooxygenase/5-Lipoxygenase Pathways and Anti-inflammatory Activity

1994 • 104 citations

Über selenhaltige aromatische Verbindungen (VI)

1924 • 104 citations

Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells

1991 • 102 citations

Oxidative Processes and Antioxidants

1995 • 100 citations

Inhibition of superoxide and nitric oxide release and protection from reoxygenation injury by ebselen in rat kupffer cells

1992 • 98 citations

Action of ebselen as an antioxidant against lipid peroxidation

1992 • 92 citations

Pharmacology of synthetic organic selenium compounds

1991 • 89 citations

Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione

1994 • 89 citations

Antioxidant effect of ebselen (PZ 51): Peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity

1992 • 83 citations

Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase.

1993 • 78 citations

N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes

1987 • 75 citations

α-(Phenylselenenyl)acetophenone derivatives with glutathione peroxidase-like activity

1992 • 71 citations

Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activity

1992 • 70 citations

Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer

1986 • 70 citations

Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals

1994 • 68 citations

Formation of thiocarbonyl compounds in the reaction of Ebselen oxide with thiols

1989 • 66 citations

A novel biologically active selenooorganic compound—VII

1988 • 65 citations

Characterisation and quantitation of a selenol intermediate in the reaction of ebselen with thiols

1992 • 64 citations

Preferential inhibition of inducible nitric oxide synthase by ebselen

1994 • 63 citations

Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.

1995 • 60 citations

Structure-activity relationships of a series of anti-inflammatory benzisoselenazolones (BISAs)

1989 • 58 citations

Reaction of peroxynitrite with L-tryptophan

1996 • 54 citations

Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: Assessment of the roles of lipid peroxidation and selenoprotein P*1

1995 • 53 citations

Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte

1994 • 53 citations

Interaction of ebselen with glutathione S-transferase and papain in vitro

1994 • 51 citations

Antioxidant activity of some diarylselenides in biological systems

1994 • 51 citations

A Novel Biologically Active Selenoorganic Compound. VIII. Biotransformation of Ebselen

1988 • 49 citations

Inhibitory Effects of Ebselen on Lipid Peroxidation in Rat Liver Microsomes

1986 • 47 citations

Reactivity of ebselen and related selenoorganic compounds with 1,2-dichloroethane radical cations and halogenated peroxyl radicals

1990 • 42 citations

Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen

1990 • 37 citations

Antioxidant Activity of Ebselen and Related Selenoorganic Compounds in Microsomal Lipid Peroxidation

1990 • 37 citations

Synthesis of ⁷⁵Se‐2‐phenyl‐1,2‐benzisoselenazol‐3(2H)‐one (PZ 51; ebselen. A novel biologically active organo‐selenium compound

1986 • 36 citations

NADPH-dependent oxidation of reduced ebselen, 2-selenylbenzanilide, and of 2-(methylseleno)benzanilide catalyzed by pig liver flavin-containing monooxygenase

1992 • 33 citations

Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor

1991 • 33 citations

Selective inhibition of leukotriene B4 formation by Ebselen: A novel approach to antiinflammatory therapy

1986 • 32 citations

Ebselen, a seleno-organic compound, protects against ethanol-induced murine gastric mucosal injury in both in vivo and in vitro systems

1995 • 31 citations

Human blood cells support the reduction of low-density-lipoprotein-associated cholesteryl ester hydroperoxides by albumin-bound ebselen

1994 • 29 citations

Redox-active chalcogen-containing glutathione peroxidase mimetics and antioxidants inhibit tumour promoter-induced downregulation of gap junctional intercellular communication between WB-F344 liver epithelial cells

1995 • 28 citations

Ebselen (PZ 51): A GSH-peroxidase-like organoselenium compound with anti-inflammatory activity.

1986 • 27 citations

Mechanism of the inhibition of hog gastric H+,K(+)-ATPase by the seleno-organic compound ebselen.

1994 • 26 citations

Catalytic effects of glutathione peroxidase mimetics on the thiol reduction of cytochrome c

1994 • 24 citations

Inhibition by Ebselen of microsomal NADPH-cytochrome P450-reductase but not

1986 • 23 citations

DEACTIVATION OF SINGLET MOLECULAR OXYGEN BY ORGANO‐SELENIUM COMPOUNDS EXHIBITING GLUTATHIONE PEROXIDASE ACTIVITY and BY SULFUR‐CONTAINING HOMOLOGS*

1991 • 22 citations

Ebselen affects calcium homeostasis in human platelets

1991 • 20 citations

Determination of the two major metabolites of ebselen in human plasma by high-performance liquid chromatography

1988 • 19 citations

Novel Ring Opening Reaction of 2-Aryl-1,2-benzisoselenazol-3(2H)-one with Thiols

1986 • 17 citations

Syntheses and Spectral Characterization of the Metabolites of a New Organo‐Selenium Drug: Ebselen

1987 • 17 citations

Microsomal metabolism of 2-(methylseleno)benzanilide

1990 • 14 citations

Metabolism and Disposition of Ebselen

1989 • 13 citations

Elimination of Plasma Phosphatidylcholine Hydroperoxide by a Seleno-Organic Compound, Ebselen

1993 • 12 citations

Influences comparatives de différentes substances séléniées et soufrées sur la fragilité des lysosomes et des mitochondries in vitro

1974 • 11 citations

Interaction of albumin-bound ebselen with rat liver glutathione S-transferase and microsomal proteins.

1994 • 11 citations

The Use of Highly Enriched 77Se in Metabolic Studies of Ebselen in Man — An NMR Investigation

1989 • 9 citations

Binding of Ebselen to Plasma Protein

1989 • 8 citations