Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

A novel biologically active seleno-organic compound—1

1984 • 810 citations

Selenium in Biology and Medicine

1989 • 586 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A novel biologically active seleno-organic compound—II

1984 • 418 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Ebselen, a selenoorganic compound as glutathione peroxidase mimic

1993 • 414 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

1983 • 277 citations

Antioxidants in Therapy and Preventive Medicine

1990 • 215 citations

The physiological consequences of glutathione variations

1992 • 200 citations

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.

1993 • 196 citations

The level and half‐life of glutathione in human plasma

1980 • 165 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)

1988 • 160 citations

A novel biologically active selenoorganic compound—IV

1985 • 151 citations

Prostaglandins and related substances: A practical approach

1988 • 146 citations

Mechanism of the Catalytic Reduction of Hydroperoxides by Ebselen : A Selenium - 77 Nmr Study

1987 • 146 citations

A novel biologically active seleno-organic compound—III

1984 • 140 citations

A novel biologically active seleno-organic compound—V

1985 • 131 citations

A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes

1987 • 110 citations

A novel biologically active seleno-organic compound—VI

1986 • 109 citations

Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.

1991 • 96 citations

Antioxidant effect of ebselen (PZ 51): Peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity

1992 • 83 citations

The mechanism of inactivation of lipoxygenases by acetylenic fatty acids

1984 • 82 citations

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

1991 • 77 citations

Investigation of the mechanism of non‐turnover‐dependent inactivation of purified human 5‐lipoxygenase

1992 • 77 citations

Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione-depleting agents in human polymorphonuclear leukocytes

1989 • 75 citations

Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer

1986 • 70 citations

[52] Lipoxygenase from rabbit reticulocytes

1981 • 66 citations

Inhibitory Effects of Ebselen on Lipid Peroxidation in Rat Liver Microsomes

1986 • 47 citations

The effect of precursors, products, and product analogs of prostaglandin cyclooxygenase upon iris sphincter muscle

1978 • 46 citations

Reactivity of ebselen and related selenoorganic compounds with 1,2-dichloroethane radical cations and halogenated peroxyl radicals

1990 • 42 citations

Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid

1992 • 41 citations

Disruption of rat hepatic microsomal electron transport chains by the selenium-containing anti-inflammatory agent Ebselen

1989 • 23 citations

Inhibition by Ebselen of microsomal NADPH-cytochrome P450-reductase but not

1986 • 23 citations

Biological Activities and Clinical Potential of Ebselen

1990 • 16 citations

Specificity of soybean lipoxygenase-1 in hydrated reverse micelles of sodiumbis(2-ethylhexyl)sulfosuccinate (aerosol OT)

1992 • 12 citations

Binding of Ebselen to Plasma Protein

1989 • 8 citations

Experience with the particulate prostaglandin endoperoxide synthase assay for testing non-steroidal antiinflammatory drugs.

1991 • 2 citations

In-vitro- und In-vivo-Beeinflussung des Leukotrienstoffwechsels durch Ebselen

1987 • 1 citations