Glutamic Acid 327 in the Sheep α1 Isoform of Na+,K+-ATPase Stabilizes a K+-induced Conformational Change

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

1985 • 762 citations

Adenosinetriphosphatase activity and the active movements of alkali metal ions

1961 • 737 citations

Molecular cloning of three distinct forms of the Na+,K+-ATPase .alpha.-subunit from rat brain

1986 • 688 citations

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 • 569 citations

Structure-function relationships in the sodium-potassium ATPase .alpha. subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

1988 • 403 citations

Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence

1985 • 375 citations

Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells.

1991 • 308 citations

Pig kidney Na⁺,K⁺‐ATPase

1986 • 207 citations

Sugar, Amino Acid, and NA+ Cotransport in the Proximal Tubule

1979 • 191 citations

Interaction of cardiac glycosides with (Na+ + K+)-activated ATPase. A biochemical link to digitalis-induced inotropy.

1984 • 186 citations

Sodium-Calcium Exchange in Plasma Membrane Vesicles

1985 • 186 citations

Sodium-Calcium Exchange in the Heart

1982 • 186 citations

A linear standard curve for the Folin Lowry determination of protein

1975 • 143 citations

Functional reconstitution of the sodium pump. Kinetics of exchange reactions performed by reconstituted Na/K-ATPase

1991 • 126 citations

Site-directed mutagenesis of the sodium-potassium-ATPase: Consequences of substitutions of negatively-charged amino acids localized in the transmembrane domains

1993 • 113 citations

Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

1992 • 109 citations

A study on the influence of the concentration of Mg2+, Pi, K+, Na+, and tris on (Mg2+ + Pi)-supported g-strophanthin binding to (Na+ + K+)-activated ATPase from ox brain

1973 • 106 citations

Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions.

1993 • 94 citations

The role of Na+ and K+ in the ouabain-inhibition of the Na+ + K+-activated membrane adenosine triphosphatase

1965 • 82 citations

Functional consequences of alterations to Glu309, Glu771, and Asp800 in the Ca(2+)-ATPase of sarcoplasmic reticulum.

1992 • 78 citations

Analysis of Amino Acid Residues in the H5-H6 Transmembrane and Extracellular Domains of Na,K-ATPase .alpha. Subunit Identifies Threonine 797 as a Determinant of Ouabain Sensitivity

1994 • 71 citations

The epitope for monoclonal antibody A20 (amino acids 870-890) is located on the luminal surface of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 71 citations

Differential expression of the Na,K-ATPase alpha 1 and alpha 2 subunit genes in a murine myogenic cell line. Induction of the alpha 2 isozyme during myocyte differentiation.

1988 • 66 citations

CrATP-induced Ca2+ occlusion in mutants of the Ca(2+)-ATPase of sarcoplasmic reticulum.

1992 • 65 citations

[19] Interaction of cardiac glycosides with Na+,K+-ATPase

1988 • 65 citations

Glutamate 329 located in the fourth transmembrane segment of the .alpha.-subunit of the rat kidney sodium-potassium-ATPase is not an essential residue for active transport of sodium and potassium ions

1993 • 63 citations

Site-directed mutagenesis of a predicted cation binding site of sodium-potassium ATPase

1993 • 62 citations

Substitution of transmembrane residues with hydrogen-bonding potential in the .alpha. subunit of sodium-potassium ATPase reveals alterations in ouabain sensitivity

1993 • 60 citations

Chemical modification of Glu-953 of the alpha chain of Na+,K(+)-ATPase associated with inactivation of cation occlusion.

1992 • 59 citations

Inactivation of Rb+ and Na+ occlusion on (Na+,K+)-ATPase by modification of carboxyl groups.

1988 • 57 citations

Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance.

1993 • 54 citations

Ligand binding sites of the ouabain-complexed (Na+ + K+)-ATPase.

1988 • 51 citations

Isolation and characterization of monoclonal antibodies to (Na+ + K+)-ATPase

1982 • 46 citations

Modification of (Na+ + K+)-dependent ATPase by fluorescein isothiocyanate: Evidence for the involvement of different amino groups at different pH values

1981 • 42 citations

[9] Preparation of antibodies to Na+,K+-ATPase and its subunits

1988 • 9 citations