Modulation of deoxycytidylate deaminase in intact human leukemia cells

Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

1965 • 1,213 citations

Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

1991 • 868 citations

INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

1988 • 773 citations

Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

1978 • 537 citations

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine.

1988 • 509 citations

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.

1990 • 393 citations

Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2'-difluoro-D-ribofuranosyl nucleosides

1988 • 353 citations

Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.

1992 • 323 citations

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

1991 • 249 citations

Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

1971 • 228 citations

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

1989 • 218 citations

An Isotopic Assay for Thymidylate Synthetase^*

1966 • 212 citations

Nucleotide Interconversions

1960 • 186 citations

Effect of aphidicolin on viral and human DNA polymerases

1979 • 152 citations

The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.

1978 • 133 citations

Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine.

1984 • 127 citations

On the Nature of a Sparing Effect by Thymidine on the Utilization of Deoxycytidine^*

1962 • 126 citations

Studies of the enzymatic deamination of ara-cytidine—V

1968 • 113 citations

The Purification and Properties of Deoxycytidylate Deaminase from Chick Embryo Extracts

1964 • 108 citations

Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro

1985 • 78 citations

Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis

1982 • 67 citations

Tetrahydrodeoxyuridylate: A potent inhibitor of deoxycytidylate deaminase

1971 • 43 citations

Deoxycytidylate deaminase. Purification and some properties of the enzyme isolated from human spleen.

1981 • 41 citations

Deoxycytidylate Deaminase and Deoxycytidine Deaminase in Normal and Neoplastic Human Tissues

1970 • 40 citations

Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine

1989 • 33 citations

Mechanism for ara-CTP catabolism in human leukemic cells and effect of deaminase inhibitors on this process.

1987 • 32 citations

In vivo rates of pyrimidine nucleotide metabolism in intact mouse T-lymphoma (s-49) cells treated with 5-fluorouracil.

1981 • 30 citations

A Tale of Two Enzymes, Deoxycytidylate Deaminase and Thymidylate Synthase

1990 • 29 citations

Degradation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human leukemic myeloblasts and lymphoblasts.

1987 • 28 citations

Human deoxycytidylate deaminase. Substrate and regulator specificities and their chemotherapeutic implications.

1983 • 26 citations

Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies.

1984 • 23 citations

Improved measurement of thymidylate synthetase activity by a modified tritium-release assay

1982 • 23 citations

Nucleotide interconversions VIII. Thymidine-sparing effect on the utilization of de-cytidine by chick-embryo mince

1963 • 22 citations

Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.

1980 • 20 citations

Kinetic behaviour and allosteric regulation of human deoxycytidylate deaminase derived from leukemic cells

1983 • 17 citations

Metabolic channeling of 5-fluoro-2'-deoxycytidine utilizing inhibitors of its deamination in cell culture.

1985 • 15 citations

Deoxycytidylate deaminase activity in lymphoproliferative disorders

1984 • 14 citations

Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2′-deoxycytidine and 1-β-d-arabinofuranosylcytosine in human leukemia cells

1991 • 12 citations

Allosteric modifier and substrate binding of donkey deoxycytidylate aminohydrolase (EC 3.5.4.12)

1991 • 10 citations

Low cytidine deaminase levels in human hematopoietic cell lines

1987 • 10 citations

Hill coefficient ratios give binding ratios of allosteric enzyme effectors; inhibition, activation, and squatting in deoxycytidylate aminohydrolase (EC 3.5.4.12)

1991 • 4 citations