Methadone N‐demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

1995 • 601 citations

Newer antidepressants and the cytochrome P450 system

1996 • 488 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Evaluation of Triacetyloleandomycin, α-Nasymphthoflavone and Diethyldithiocarbamate as Selective Chemical Probes for Inhibition of Human Cytochromes P450

1994 • 252 citations

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

1995 • 243 citations

Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

1996 • 242 citations

Involvement of Cytochrome P450 3A4 Enzyme in the N-Demethylation of Methadone in Human Liver Microsomes

1996 • 225 citations

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1993 • 225 citations

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

1995 • 224 citations

Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms.

1994 • 223 citations

Rifampin-Induced Methadone Withdrawal

1976 • 213 citations

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

1997 • 208 citations

An update on the clinical use of methadone for cancer pain

1997 • 189 citations

Altered methadone pharmacokinetics in methadone-maintained pregnant women.

1985 • 178 citations

Inhibition of Alprazolam and Desipramine Hydroxylation In Vitro by Paroxetine and Fluvoxamine

1995 • 174 citations

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

1994 • 171 citations

Inhibitors of alprazolam metabolism in vitro: effect of serotonin‐ reuptake‐inhibitor antidepressants, ketoconazole and quinidine.

1994 • 162 citations

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1988 • 152 citations

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.

1994 • 144 citations

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.

1997 • 134 citations

Stereoselective Pharmacokinetics of Methadone in Chronic Pain Patients

1996 • 127 citations

Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors.

1998 • 127 citations

Binding of d-methadone, 1-methadone, and dl-methadone to proteins in plasma of healthy volunteers: Role of the variants of α1-acid glycoprotein

1990 • 126 citations

Phenytoin-Induced Methadone Withdrawal

1981 • 118 citations

Methadone binding to orosomucoid (α1-acid glycoprotein): Determinant of free fraction in plasma

1981 • 117 citations

Urinary metabolites of DL-methadone in maintenance subjects

1973 • 106 citations

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.

1993 • 102 citations

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.

1994 • 101 citations

Disposition of methadone in methadone maintenance

1975 • 96 citations

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4

1997 • 94 citations

Pharmacologic comparison of the optical isomers of methadon.

1948 • 67 citations

Diazepam and methadone blood levels following concurrent administration of diazepam and methadone

1986 • 45 citations

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome

1984 • 45 citations

In vitro evidence against the oxidation of quinidine by the sparteine/debrisoquine monooxygenase of human liver.

1988 • 45 citations

Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts

1982 • 43 citations

Increase in desipramine serum levels associated with methadone treatment

1989 • 38 citations

The addiction liability of some drugs of the methadon series.

1948 • 37 citations

Evidence for Altered Desipramine Disposition in Methadone-Maintained Patients Treated for Cocaine Abuse

1990 • 33 citations

Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.

1989 • 31 citations

Daily variations in phenylalanine hydroxylase activity in male and female guinea pigs

1972 • 27 citations

Association between CYP2C19 genotype and proguanil oxidative polymorphism

1997 • 20 citations

Carbamazepine treatment of cocaine dependence in methadone maintenance patients with dual opiate-cocaine addiction.

1989 • 18 citations

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